Names & Taxonomy
- Uniprot ID:
- Q16762
- Entry Name:
- THTR_HUMAN
- Status:
- reviewed
- Protein Names:
- Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese)
- Gene Names:
- TST
- Gene Names Primary:
- TST
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 297
- Sequence:
- MVHQVLYRALVSTKWLAESIRTGKLGPGLRVLDASWYSPGTREARKEYLERHVPGASFFDIEECRDTASPYEMMLPSEAGFAEYVGRLGISNHTHVVVYDGEHLGSFYAPRVWWMFRVFGHRTVSVLNGGFRNWLKEGHPVTSEPSRPEPAVFKATLDRSLLKTYEQVLENLESKRFQLVDSRSQGRFLGTEPEPDAVGLDSGHIRGAVNMPFMDFLTEDGFEKGPEELRALFQTKKVDLSQPLIATCRKGVTACHVALAAYLCGKPDVAVYDGSWSEWFRRAPPESRVSQGKSEKA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix.
Function
- Function:
- Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA.
- Catalytic Activity:
- Thiosulfate + cyanide = sulfite + thiocyanate.
- Active Site:
- ACT_SITE 248 248 Cysteine persulfide intermediate.
- Gene Ontology Go:
- extracellular exosome
extracellular space
mitochondrial inner membrane
mitochondrial matrix
mitochondrion
5S rRNA binding
thiosulfate sulfurtransferase activity
cellular nitrogen compound metabolic process
cyanate catabolic process
epithelial cell differentiation
rRNA import into mitochondrion
rRNA transport
small molecule metabolic process
sulfide oxidation, using sulfide:quinone oxidoreductase
sulfur amino acid catabolic process
sulfur amino acid metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
cyanate catabolic process
epithelial cell differentiation
rRNA import into mitochondrion
rRNA transport
small molecule metabolic process
sulfide oxidation, using sulfide:quinone oxidoreductase
sulfur amino acid catabolic process
sulfur amino acid metabolic process - Gene Ontology Molecular Function:
- 5S rRNA binding
thiosulfate sulfurtransferase activity - Gene Ontology Cellular Component:
- extracellular exosome
extracellular space
mitochondrial inner membrane
mitochondrial matrix
mitochondrion - Keywords:
- Acetylation
Complete proteome
Direct protein sequencing
Glycoprotein
Mitochondrion
Phosphoprotein
Polymorphism
RNA-binding
Reference proteome
Repeat
Transferase