Names & Taxonomy
- Uniprot ID:
- Q16760
- Entry Name:
- DGKD_HUMAN
- Status:
- reviewed
- Protein Names:
- Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK-delta)
- Gene Names:
- DGKD KIAA0145
- Gene Names Primary:
- DGKD
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1214
- Sequence:
- MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLCKVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEESEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRLVASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSESEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDGLPALNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKSWEDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRDMEQELAHAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQLDPPQKEQLGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFKKEKNNKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLGVTKVGHMKRILCGIKELSRSAPAVEA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 2: Cytoplasm
Function
- Function:
- May function as signaling molecule.
- Catalytic Activity:
- ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
- Enzyme Regulation:
- ENZYME REGULATION: Partially inhibited by phosphatidylserine.
- Cross Reference Drug Bank:
- DB00144
- Gene Ontology Go:
- cytoplasm
cytoplasmic, membrane-bounded vesicle
plasma membrane
ATP binding
diacylglycerol binding
diacylglycerol kinase activity
metal ion binding
protein heterodimerization activity
protein homodimerization activity
blood coagulation
cell growth
diacylglycerol metabolic process
endocytosis
epidermal growth factor receptor signaling pathway
multicellular organism development
platelet activation
protein homooligomerization
protein kinase C-activating G-protein coupled receptor signaling pathway
protein transport
response to organic substance
second-messenger-mediated signaling
signal transduction - Gene Ontology Biological Process:
- blood coagulation
cell growth
diacylglycerol metabolic process
endocytosis
epidermal growth factor receptor signaling pathway
multicellular organism development
platelet activation
protein homooligomerization
protein kinase C-activating G-protein coupled receptor signaling pathway
protein transport
response to organic substance
second-messenger-mediated signaling
signal transduction - Gene Ontology Molecular Function:
- ATP binding
diacylglycerol binding
diacylglycerol kinase activity
metal ion binding
protein heterodimerization activity
protein homodimerization activity - Gene Ontology Cellular Component:
- cytoplasm
cytoplasmic, membrane-bounded vesicle
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Complete proteome
Cytoplasm
Endocytosis
Kinase
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Protein transport
Reference proteome
Repeat
Transferase
Transport
Zinc
Zinc-finger - Interacts With:
- O75923