Names & Taxonomy
- Uniprot ID:
- Q16698
- Entry Name:
- DECR_HUMAN
- Status:
- reviewed
- Protein Names:
- 2,4-dienoyl-CoA reductase, mitochondrial (EC 1.3.1.34) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]) (Short chain dehydrogenase/reductase family 18C member 1)
- Gene Names:
- DECR1 DECR SDR18C1
- Gene Names Primary:
- DECR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 335
- Sequence:
- MKLPARVFFTLGSRLPCGLAPRRFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDLRKVTKEQWDTIEELIRKTKGS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion.
Function
- Function:
- Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
- Catalytic Activity:
- Trans-2,3-didehydroacyl-CoA + NADP(+) = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=7.7 uM for NADPH
- Active Site:
- ACT_SITE 199 199 Proton acceptor.
- Gene Ontology Go:
- cytoplasm
extracellular exosome
mitochondrial matrix
mitochondrion
nucleoplasm
nucleus
2,4-dienoyl-CoA reductase (NADPH) activity
NADPH binding
oxidoreductase activity, acting on NAD(P)H
cellular lipid metabolic process
fatty acid beta-oxidation
protein homotetramerization
small molecule metabolic process - Gene Ontology Biological Process:
- cellular lipid metabolic process
fatty acid beta-oxidation
protein homotetramerization
small molecule metabolic process - Gene Ontology Molecular Function:
- 2,4-dienoyl-CoA reductase (NADPH) activity
NADPH binding
oxidoreductase activity, acting on NAD(P)H - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome
mitochondrial matrix
mitochondrion
nucleoplasm
nucleus - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Fatty acid metabolism
Lipid metabolism
Mitochondrion
NADP
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Transit peptide