Names & Taxonomy
- Uniprot ID:
- Q16613
- Entry Name:
- SNAT_HUMAN
- Status:
- reviewed
- Protein Names:
- Serotonin N-acetyltransferase (Serotonin acetylase) (EC 2.3.1.87) (Aralkylamine N-acetyltransferase) (AA-NAT)
- Gene Names:
- AANAT SNAT
- Gene Names Primary:
- AANAT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 207
- Sequence:
- MSTQSTHPLKPEAPRLPPGIPESPSCQRRHTLPASEFRCLTPEDAVSAFEIEREAFISVLGVCPLYLDEIRHFLTLCPELSLGWFEEGCLVAFIIGSLWDKERLMQESLTLHRSGGHIAHLHVLAVHRAFRQQGRGPILLWRYLHHLGSQPAVRRAALMCEDALVPFYERFSFHAVGPCAITVGSLTFMELHCSLRGHPFLRRNSGC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
- Pathway:
- Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.
- Catalytic Activity:
- Acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.13 mM for tryptamine
- Gene Ontology Go:
- cytosol
perinuclear region of cytoplasm
aralkylamine N-acetyltransferase activity
arylamine N-acetyltransferase activity
cellular nitrogen compound metabolic process
cellular response to cAMP
circadian rhythm
indolalkylamine biosynthetic process
melatonin biosynthetic process
N-terminal protein amino acid acetylation
photoperiodism
response to calcium ion
response to copper ion
response to corticosterone
response to cytokine
response to insulin
response to prostaglandin E
response to zinc ion
small molecule metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
cellular response to cAMP
circadian rhythm
indolalkylamine biosynthetic process
melatonin biosynthetic process
N-terminal protein amino acid acetylation
photoperiodism
response to calcium ion
response to copper ion
response to corticosterone
response to cytokine
response to insulin
response to prostaglandin E
response to zinc ion
small molecule metabolic process - Gene Ontology Molecular Function:
- aralkylamine N-acetyltransferase activity
arylamine N-acetyltransferase activity - Gene Ontology Cellular Component:
- cytosol
perinuclear region of cytoplasm - Keywords:
- Acyltransferase
Alternative splicing
Biological rhythms
Complete proteome
Cytoplasm
Disease mutation
Melatonin biosynthesis
Phosphoprotein
Polymorphism
Reference proteome
Transferase - Interacts With:
- O14503; Q99750