Names & Taxonomy

Uniprot ID:
Q16552
Entry Name:
IL17_HUMAN
Status:
reviewed
Protein Names:
Interleukin-17A (IL-17) (IL-17A) (Cytotoxic T-lymphocyte-associated antigen 8) (CTLA-8)
Gene Names:
IL17A CTLA8 IL17
Gene Names Primary:
IL17A
Organism:
Homo sapiens (Human)

Structure

Length:
155
Sequence:
MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).
Cross Reference Drug Bank:
DB09029
Gene Ontology Go:
cytoplasm
external side of plasma membrane
extracellular space
cytokine activity
cytokine receptor binding
apoptotic process
cell death
cell surface receptor signaling pathway
cell-cell signaling
cellular response to glucocorticoid stimulus
cellular response to interleukin-1
defense response to fungus
fibroblast activation
immune response
inflammatory response
positive regulation of cytokine production involved in inflammatory response
positive regulation of interleukin-23 production
positive regulation of interleukin-6 secretion
positive regulation of necrotic cell death
positive regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
response to amino acid
Gene Ontology Biological Process:
apoptotic process
cell-cell signaling
cell death
cell surface receptor signaling pathway
cellular response to glucocorticoid stimulus
cellular response to interleukin-1
defense response to fungus
fibroblast activation
immune response
inflammatory response
positive regulation of cytokine production involved in inflammatory response
positive regulation of interleukin-23 production
positive regulation of interleukin-6 secretion
positive regulation of necrotic cell death
positive regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
response to amino acid
Gene Ontology Molecular Function:
cytokine activity
cytokine receptor binding
Gene Ontology Cellular Component:
cytoplasm
external side of plasma membrane
extracellular space
Keywords:
3D-structure
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Signal
Interacts With:
Q9BQC3

Publication

PubMed ID:
8676080 7499828 14574404 15489334 15340161 17355969 17911633 18684971 19835883