Names & Taxonomy

Uniprot ID:
Q16515
Entry Name:
ASIC2_HUMAN
Status:
reviewed
Protein Names:
Acid-sensing ion channel 2 (ASIC2) (Amiloride-sensitive brain sodium channel) (Amiloride-sensitive cation channel 1, neuronal) (Amiloride-sensitive cation channel neuronal 1) (Brain sodium channel 1) (BNC1) (BNaC1) (Mammalian degenerin homolog)
Gene Names:
ASIC2 ACCN ACCN1 BNAC1 MDEG
Gene Names Primary:
ASIC2
Organism:
Homo sapiens (Human)

Structure

Length:
512
Sequence:
MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPSVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHSETISHTVNVPLQTTLGTLEEIAC
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
Cross Reference Drug Bank:
DB00594
Gene Ontology Go:
dendritic spine
integral component of plasma membrane
neuronal cell body
plasma membrane
ion gated channel activity
ligand-gated sodium channel activity
central nervous system development
detection of mechanical stimulus involved in sensory perception
ion transmembrane transport
monovalent inorganic cation transport
negative regulation of apoptotic process
peripheral nervous system development
phototransduction
positive regulation of synapse assembly
protein localization to synapse
regulation of blood coagulation
regulation of gene expression
regulation of ion transmembrane transport
regulation of membrane potential
regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
regulation of vasoconstriction
response to acidic pH
sensory perception of sound
sensory perception of sour taste
synaptic transmission
transmembrane transport
Gene Ontology Biological Process:
central nervous system development
detection of mechanical stimulus involved in sensory perception
ion transmembrane transport
monovalent inorganic cation transport
negative regulation of apoptotic process
peripheral nervous system development
phototransduction
positive regulation of synapse assembly
protein localization to synapse
regulation of blood coagulation
regulation of gene expression
regulation of ion transmembrane transport
regulation of membrane potential
regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
regulation of vasoconstriction
response to acidic pH
sensory perception of sound
sensory perception of sour taste
synaptic transmission
transmembrane transport
Gene Ontology Molecular Function:
ion gated channel activity
ligand-gated sodium channel activity
Gene Ontology Cellular Component:
dendritic spine
integral component of plasma membrane
neuronal cell body
plasma membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Sodium channel
Sodium transport
Transmembrane
Transmembrane helix
Transport
Interacts With:
Q9NRD5

Publication

PubMed ID:
8626462 8631835 9037075 17974005 16625196 15489334 10842183 11802773