Names & Taxonomy

Uniprot ID:
Q16478
Entry Name:
GRIK5_HUMAN
Status:
reviewed
Protein Names:
Glutamate receptor ionotropic, kainate 5 (GluK5) (Excitatory amino acid receptor 2) (EAA2) (Glutamate receptor KA-2) (KA2)
Gene Names:
GRIK5 GRIK2
Gene Names Primary:
GRIK5
Organism:
Homo sapiens (Human)

Structure

Length:
980
Sequence:
MPAELLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGSAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGVPAEATSPPRPRPGPAGPRELAEHE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Function

Function:
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD.
Gene Ontology Go:
cell junction
dendrite
endoplasmic reticulum
kainate selective glutamate receptor complex
perikaryon
plasma membrane
postsynaptic density
postsynaptic membrane
presynaptic membrane
terminal bouton
extracellular-glutamate-gated ion channel activity
kainate selective glutamate receptor activity
cellular response to glucose stimulus
establishment of localization in cell
excitatory postsynaptic potential
positive regulation of neuron apoptotic process
protein retention in ER lumen
receptor clustering
regulation of synaptic vesicle fusion to presynaptic membrane
synaptic transmission
synaptic transmission, glutamatergic
Gene Ontology Biological Process:
cellular response to glucose stimulus
establishment of localization in cell
excitatory postsynaptic potential
positive regulation of neuron apoptotic process
protein retention in ER lumen
receptor clustering
regulation of synaptic vesicle fusion to presynaptic membrane
synaptic transmission
synaptic transmission, glutamatergic
Gene Ontology Molecular Function:
extracellular-glutamate-gated ion channel activity
kainate selective glutamate receptor activity
Gene Ontology Cellular Component:
cell junction
dendrite
endoplasmic reticulum
kainate selective glutamate receptor complex
perikaryon
plasma membrane
postsynaptic density
postsynaptic membrane
presynaptic membrane
terminal bouton
Keywords:
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
1321949