Names & Taxonomy
- Uniprot ID:
- Q16222
- Entry Name:
- UAP1_HUMAN
- Status:
- reviewed
- Protein Names:
- UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Sperm-associated antigen 2) [Includes: UDP-N-acetylgalactosamine pyrophosphorylase (EC 2.7.7.83) (AGX-1); UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (AGX-2)]
- Gene Names:
- UAP1 SPAG2
- Gene Names Primary:
- UAP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 522
- Sequence:
- MNINDLKLTLSKAGQEHLLRFWNELEEAQQVELYAELQAMNFEELNFFFQKAIEGFNQSSHQKNVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAYPKGMYDVGLPSRKTLFQIQAERILKLQQVAEKYYGNKCIIPWYIMTSGRTMESTKEFFTKHKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQVVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNVYEPQLQHHVAQKKIPYVDTQGQLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTTARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATNGKSETITADVNHNLKDANDVPIQCEISPLISYAGEGLESYVADKEFHAPLIIDENGVHELVKNGI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Note=In spermatozoa, localized to the principal piece of the tail, the neck region of the head and to a lesser extent, the midpiece of the tail.
Function
- Function:
- Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.
- Pathway:
- Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.
- Catalytic Activity:
- UTP + N-acetyl-alpha-D-galactosamine 1-phosphate = diphosphate + UDP-N-acetyl-alpha-D-galactosamine.
- Gene Ontology Go:
- cytoplasm
cytosol
nucleoplasm
plasma membrane
carbohydrate binding
identical protein binding
UDP-N-acetylglucosamine diphosphorylase activity
cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
post-translational protein modification
protein N-linked glycosylation via asparagine
UDP-N-acetylglucosamine biosynthetic process - Gene Ontology Biological Process:
- cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
post-translational protein modification
protein N-linked glycosylation via asparagine
UDP-N-acetylglucosamine biosynthetic process - Gene Ontology Molecular Function:
- carbohydrate binding
identical protein binding
UDP-N-acetylglucosamine diphosphorylase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
nucleoplasm
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Nucleotidyltransferase
Polymorphism
Reference proteome
Transferase - Interacts With:
- Itself