Names & Taxonomy
- Uniprot ID:
- Q15822
- Entry Name:
- ACHA2_HUMAN
- Status:
- reviewed
- Protein Names:
- Neuronal acetylcholine receptor subunit alpha-2
- Gene Names:
- CHRNA2
- Gene Names Primary:
- CHRNA2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 529
- Sequence:
- MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Function
- Function:
- After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
- Cross Reference Drug Bank:
- DB00732 DB00810 DB00411 DB00565 DB01245 DB00514 DB01135 DB00898 DB00674 DB00483 DB00657 DB01336 DB01226 DB00184 DB01337 DB01338 DB00721 DB00728 DB01199 DB01339
- Gene Ontology Go:
- acetylcholine-gated channel complex
cell junction
integral component of membrane
plasma membrane
postsynaptic membrane
acetylcholine binding
acetylcholine receptor activity
acetylcholine-activated cation-selective channel activity
drug binding
chemical synaptic transmission, postsynaptic
ion transport
neuromuscular synaptic transmission
protein heterooligomerization
response to nicotine
signal transduction
synaptic transmission
synaptic transmission, cholinergic - Gene Ontology Biological Process:
- chemical synaptic transmission, postsynaptic
ion transport
neuromuscular synaptic transmission
protein heterooligomerization
response to nicotine
signal transduction
synaptic transmission
synaptic transmission, cholinergic - Gene Ontology Molecular Function:
- acetylcholine-activated cation-selective channel activity
acetylcholine binding
acetylcholine receptor activity
drug binding - Gene Ontology Cellular Component:
- acetylcholine-gated channel complex
cell junction
integral component of membrane
plasma membrane
postsynaptic membrane - Keywords:
- Alternative splicing
Cell junction
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Epilepsy
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport