Names & Taxonomy

Uniprot ID:
Q15822
Entry Name:
ACHA2_HUMAN
Status:
reviewed
Protein Names:
Neuronal acetylcholine receptor subunit alpha-2
Gene Names:
CHRNA2
Gene Names Primary:
CHRNA2
Organism:
Homo sapiens (Human)

Structure

Length:
529
Sequence:
MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Function

Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Cross Reference Drug Bank:
DB00732 DB00810 DB00411 DB00565 DB01245 DB00514 DB01135 DB00898 DB00674 DB00483 DB00657 DB01336 DB01226 DB00184 DB01337 DB01338 DB00721 DB00728 DB01199 DB01339
Gene Ontology Go:
acetylcholine-gated channel complex
cell junction
integral component of membrane
plasma membrane
postsynaptic membrane
acetylcholine binding
acetylcholine receptor activity
acetylcholine-activated cation-selective channel activity
drug binding
chemical synaptic transmission, postsynaptic
ion transport
neuromuscular synaptic transmission
protein heterooligomerization
response to nicotine
signal transduction
synaptic transmission
synaptic transmission, cholinergic
Gene Ontology Biological Process:
chemical synaptic transmission, postsynaptic
ion transport
neuromuscular synaptic transmission
protein heterooligomerization
response to nicotine
signal transduction
synaptic transmission
synaptic transmission, cholinergic
Gene Ontology Molecular Function:
acetylcholine-activated cation-selective channel activity
acetylcholine binding
acetylcholine receptor activity
drug binding
Gene Ontology Cellular Component:
acetylcholine-gated channel complex
cell junction
integral component of membrane
plasma membrane
postsynaptic membrane
Keywords:
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Epilepsy
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
8906617 14702039 16421571 15489334 16826524