Names & Taxonomy

Uniprot ID:
Q15661
Entry Name:
TRYB1_HUMAN
Status:
reviewed
Protein Names:
Tryptase alpha/beta-1 (Tryptase-1) (EC 3.4.21.59) (Tryptase I) (Tryptase alpha-1)
Gene Names:
TPSAB1 TPS1 TPS2 TPSB1
Gene Names Primary:
TPSAB1
Organism:
Homo sapiens (Human)

Structure

Length:
275
Sequence:
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted. Note=Released from the secretory granules upon mast cell activation.

Function

Function:
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315).
Catalytic Activity:
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.
Active Site:
ACT_SITE 74 74 Charge relay system.; ACT_SITE 121 121 Charge relay system.; ACT_SITE 224 224 Charge relay system.
Gene Ontology Go:
extracellular region
extracellular space
serine-type endopeptidase activity
serine-type peptidase activity
defense response
extracellular matrix disassembly
extracellular matrix organization
Gene Ontology Biological Process:
defense response
extracellular matrix disassembly
extracellular matrix organization
Gene Ontology Molecular Function:
serine-type endopeptidase activity
serine-type peptidase activity
Gene Ontology Cellular Component:
extracellular region
extracellular space
Keywords:
3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Polymorphism
Protease
Reference proteome
Secreted
Serine protease
Signal
Zymogen
Interacts With:
P16333; P27986

Publication

PubMed ID:
2677049 2187193 9920877 18854315 19748655 15616553 15489334 3543004 14670919 18039527 19159218 25944712 12162961 10898108