Names & Taxonomy
- Uniprot ID:
- Q15661
- Entry Name:
- TRYB1_HUMAN
- Status:
- reviewed
- Protein Names:
- Tryptase alpha/beta-1 (Tryptase-1) (EC 3.4.21.59) (Tryptase I) (Tryptase alpha-1)
- Gene Names:
- TPSAB1 TPS1 TPS2 TPSB1
- Gene Names Primary:
- TPSAB1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 275
- Sequence:
- MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted. Note=Released from the secretory granules upon mast cell activation.
Function
- Function:
- Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315).
- Catalytic Activity:
- Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.
- Active Site:
- ACT_SITE 74 74 Charge relay system.; ACT_SITE 121 121 Charge relay system.; ACT_SITE 224 224 Charge relay system.
- Gene Ontology Go:
- extracellular region
extracellular space
serine-type endopeptidase activity
serine-type peptidase activity
defense response
extracellular matrix disassembly
extracellular matrix organization - Gene Ontology Biological Process:
- defense response
extracellular matrix disassembly
extracellular matrix organization - Gene Ontology Molecular Function:
- serine-type endopeptidase activity
serine-type peptidase activity - Gene Ontology Cellular Component:
- extracellular region
extracellular space - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Polymorphism
Protease
Reference proteome
Secreted
Serine protease
Signal
Zymogen - Interacts With:
- P16333; P27986