Names & Taxonomy
- Uniprot ID:
- Q15596
- Entry Name:
- NCOA2_HUMAN
- Status:
- reviewed
- Protein Names:
- Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2)
- Gene Names:
- NCOA2 BHLHE75 SRC2 TIF2
- Gene Names Primary:
- NCOA2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1464
- Sequence:
- MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKEEGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLSSNINFPINGPKEQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPGQPTSMLSPRHRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSDQMEPSPLASSLSDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKDLSQESSSTAPGSEVTIKQEPVSPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSAVRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSELEMNMGGPQYSQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRALGIPELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRLQLQHRLQAQQNRQPLMNQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQSPPHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDTTRKYC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus.
Function
- Function:
- Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).
- Gene Ontology Go:
- dendritic spine
Golgi apparatus
microtubule
neuronal cell body
nucleoplasm
nucleus
postsynaptic density
presynaptic active zone
rough endoplasmic reticulum
chromatin binding
histone acetyltransferase activity
ligand-dependent nuclear receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
nuclear hormone receptor binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
thyroid hormone receptor coactivator activity
transcription coactivator activity
bile acid and bile salt transport
bile acid metabolic process
cellular lipid metabolic process
cellular response to hormone stimulus
cellular response to Thyroglobulin triiodothyronine
cerebellum development
chromatin organization
circadian regulation of gene expression
locomotor rhythm
male gonad development
negative regulation of transcription from RNA polymerase II promoter
positive regulation of female receptivity
positive regulation of glucocorticoid receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
regulation of glucose metabolic process
regulation of transcription, DNA-templated
small GTPase mediated signal transduction
small molecule metabolic process
transcription, DNA-templated - Gene Ontology Biological Process:
- bile acid and bile salt transport
bile acid metabolic process
cellular lipid metabolic process
cellular response to hormone stimulus
cellular response to Thyroglobulin triiodothyronine
cerebellum development
chromatin organization
circadian regulation of gene expression
locomotor rhythm
male gonad development
negative regulation of transcription from RNA polymerase II promoter
positive regulation of female receptivity
positive regulation of glucocorticoid receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
regulation of glucose metabolic process
regulation of transcription, DNA-templated
small GTPase mediated signal transduction
small molecule metabolic process
transcription, DNA-templated - Gene Ontology Molecular Function:
- chromatin binding
histone acetyltransferase activity
ligand-dependent nuclear receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
nuclear hormone receptor binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
thyroid hormone receptor coactivator activity
transcription coactivator activity - Gene Ontology Cellular Component:
- dendritic spine
Golgi apparatus
microtubule
neuronal cell body
nucleoplasm
nucleus
postsynaptic density
presynaptic active zone
rough endoplasmic reticulum - Keywords:
- 3D-structure
Acetylation
Activator
Biological rhythms
Complete proteome
Isopeptide bond
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transcription
Transcription regulation
Ubl conjugation - Interacts With:
- P10275; Q92841; P03372