Names & Taxonomy
- Uniprot ID:
- Q15166
- Entry Name:
- PON3_HUMAN
- Status:
- reviewed
- Protein Names:
- Serum paraoxonase/lactonase 3 (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1)
- Gene Names:
- PON3
- Gene Names Primary:
- PON3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 354
- Sequence:
- MGKLVALVLLGVGLSLVGEMFLAFRERVNASREVEPVEPENCHLIEELESGSEDIDILPSGLAFISSGLKYPGMPNFAPDEPGKIFLMDLNEQNPRAQALEISGGFDKELFNPHGISIFIDKDNTVYLYVVNHPHMKSTVEIFKFEEQQRSLVYLKTIKHELLKSVNDIVVLGPEQFYATRDHYFTNSLLSFFEMILDLRWTYVLFYSPREVKVVAKGFCSANGITVSADQKYVYVADVAAKNIHIMEKHDNWDLTQLKVIQLGTLVDNLTVDPATGDILAGCHPNPMKLLNYNPEDPPGSEVLRIQNVLSEKPRVSTVYANNGSVLQGTSVASVYHGKILIGTVFHKTLYCEL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space
Function
- Function:
- Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
- Catalytic Activity:
- A phenyl acetate + H(2)O = a phenol + acetate.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Active Site:
- ACT_SITE 114 114 Proton acceptor.
- Cross Reference Drug Bank:
- DB00974 DB00227
- Gene Ontology Go:
- extracellular exosome
extracellular space
intracellular membrane-bounded organelle
3,4-dihydrocoumarin hydrolase activity
acyl-L-homoserine-lactone lactonohydrolase activity
aryldialkylphosphatase activity
arylesterase activity
dihydrocoumarin hydrolase activity
metal ion binding
protein homodimerization activity
aromatic compound catabolic process
carboxylic acid catabolic process
coumarin catabolic process
negative regulation of superoxide anion generation
phenylacetate catabolic process
response to external stimulus
response to toxic substance - Gene Ontology Biological Process:
- aromatic compound catabolic process
carboxylic acid catabolic process
coumarin catabolic process
negative regulation of superoxide anion generation
phenylacetate catabolic process
response to external stimulus
response to toxic substance - Gene Ontology Molecular Function:
- 3,4-dihydrocoumarin hydrolase activity
acyl-L-homoserine-lactone lactonohydrolase activity
aryldialkylphosphatase activity
arylesterase activity
dihydrocoumarin hydrolase activity
metal ion binding
protein homodimerization activity - Gene Ontology Cellular Component:
- extracellular exosome
extracellular space
intracellular membrane-bounded organelle - Keywords:
- Calcium
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Secreted
Signal