Names & Taxonomy

Uniprot ID:
Q15166
Entry Name:
PON3_HUMAN
Status:
reviewed
Protein Names:
Serum paraoxonase/lactonase 3 (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1)
Gene Names:
PON3
Gene Names Primary:
PON3
Organism:
Homo sapiens (Human)

Structure

Length:
354
Sequence:
MGKLVALVLLGVGLSLVGEMFLAFRERVNASREVEPVEPENCHLIEELESGSEDIDILPSGLAFISSGLKYPGMPNFAPDEPGKIFLMDLNEQNPRAQALEISGGFDKELFNPHGISIFIDKDNTVYLYVVNHPHMKSTVEIFKFEEQQRSLVYLKTIKHELLKSVNDIVVLGPEQFYATRDHYFTNSLLSFFEMILDLRWTYVLFYSPREVKVVAKGFCSANGITVSADQKYVYVADVAAKNIHIMEKHDNWDLTQLKVIQLGTLVDNLTVDPATGDILAGCHPNPMKLLNYNPEDPPGSEVLRIQNVLSEKPRVSTVYANNGSVLQGTSVASVYHGKILIGTVFHKTLYCEL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted, extracellular space

Function

Function:
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
Catalytic Activity:
A phenyl acetate + H(2)O = a phenol + acetate.
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Active Site:
ACT_SITE 114 114 Proton acceptor.
Cross Reference Drug Bank:
DB00974 DB00227
Gene Ontology Go:
extracellular exosome
extracellular space
intracellular membrane-bounded organelle
3,4-dihydrocoumarin hydrolase activity
acyl-L-homoserine-lactone lactonohydrolase activity
aryldialkylphosphatase activity
arylesterase activity
dihydrocoumarin hydrolase activity
metal ion binding
protein homodimerization activity
aromatic compound catabolic process
carboxylic acid catabolic process
coumarin catabolic process
negative regulation of superoxide anion generation
phenylacetate catabolic process
response to external stimulus
response to toxic substance
Gene Ontology Biological Process:
aromatic compound catabolic process
carboxylic acid catabolic process
coumarin catabolic process
negative regulation of superoxide anion generation
phenylacetate catabolic process
response to external stimulus
response to toxic substance
Gene Ontology Molecular Function:
3,4-dihydrocoumarin hydrolase activity
acyl-L-homoserine-lactone lactonohydrolase activity
aryldialkylphosphatase activity
arylesterase activity
dihydrocoumarin hydrolase activity
metal ion binding
protein homodimerization activity
Gene Ontology Cellular Component:
extracellular exosome
extracellular space
intracellular membrane-bounded organelle
Keywords:
Calcium
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Secreted
Signal

Publication

PubMed ID:
12690205 12853948 15489334 8661009 15772423 16335952 19690332 24275569