Names & Taxonomy
- Uniprot ID:
- Q15120
- Entry Name:
- PDK3_HUMAN
- Status:
- reviewed
- Protein Names:
- [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)
- Gene Names:
- PDK3 PDHK3
- Gene Names Primary:
- PDK3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 406
- Sequence:
- MRLFRWLLKQPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIKVRNRHNDVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRLFNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKAKQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix.
Function
- Function:
- Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species.
- Catalytic Activity:
- ATP + = ADP + phosphate.
- Enzyme Regulation:
- ENZYME REGULATION: Activated by interaction with DLAT. Inhibited by AZD7545, dichloroacetate and radicicol.
- Gene Ontology Go:
- mitochondrial matrix
mitochondrion
ATP binding
protein kinase activity
protein serine/threonine kinase activity
pyruvate dehydrogenase (acetyl-transferring) kinase activity
cellular metabolic process
cellular response to fatty acid
cellular response to glucose stimulus
glucose metabolic process
hypoxia-inducible factor-1alpha signaling pathway
peptidyl-serine phosphorylation
peroxisome proliferator activated receptor signaling pathway
pyruvate metabolic process
regulation of acetyl-CoA biosynthetic process from pyruvate
regulation of glucose metabolic process
regulation of reactive oxygen species metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- cellular metabolic process
cellular response to fatty acid
cellular response to glucose stimulus
glucose metabolic process
hypoxia-inducible factor-1alpha signaling pathway
peptidyl-serine phosphorylation
peroxisome proliferator activated receptor signaling pathway
pyruvate metabolic process
regulation of acetyl-CoA biosynthetic process from pyruvate
regulation of glucose metabolic process
regulation of reactive oxygen species metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- ATP binding
protein kinase activity
protein serine/threonine kinase activity
pyruvate dehydrogenase (acetyl-transferring) kinase activity - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrion - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Carbohydrate metabolism
Charcot-Marie-Tooth disease
Complete proteome
Disease mutation
Glucose metabolism
Kinase
Mitochondrion
Neurodegeneration
Neuropathy
Nucleotide-binding
Polymorphism
Reference proteome
Transferase
Transit peptide