Names & Taxonomy

Uniprot ID:
Q15116
Entry Name:
PDCD1_HUMAN
Status:
reviewed
Protein Names:
Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)
Gene Names:
PDCD1 PD1
Gene Names Primary:
PDCD1
Organism:
Homo sapiens (Human)

Structure

Length:
288
Sequence:
MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Function

Function:
Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.
Cross Reference Drug Bank:
DB09035 DB09037
Gene Ontology Go:
external side of plasma membrane
integral component of membrane
plasma membrane
signal transducer activity
apoptotic process
humoral immune response
multicellular organism development
negative regulation of apoptotic process
negative regulation of tolerance induction
positive regulation of T cell apoptotic process
signal transduction
T cell costimulation
Gene Ontology Biological Process:
apoptotic process
humoral immune response
multicellular organism development
negative regulation of apoptotic process
negative regulation of tolerance induction
positive regulation of T cell apoptotic process
signal transduction
T cell costimulation
Gene Ontology Molecular Function:
signal transducer activity
Gene Ontology Cellular Component:
external side of plasma membrane
integral component of membrane
plasma membrane
Keywords:
3D-structure
Apoptosis
Complete proteome
Disulfide bond
Glycoprotein
Immunity
Immunoglobulin domain
Membrane
Polymorphism
Reference proteome
Signal
Systemic lupus erythematosus
Transmembrane
Transmembrane helix
Interacts With:
Q9NZQ7

Publication

PubMed ID:
7851902 9332365 12402038 14702039 15489334 21276005