Names & Taxonomy
- Uniprot ID:
- Q15116
- Entry Name:
- PDCD1_HUMAN
- Status:
- reviewed
- Protein Names:
- Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)
- Gene Names:
- PDCD1 PD1
- Gene Names Primary:
- PDCD1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 288
- Sequence:
- MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.
- Cross Reference Drug Bank:
- DB09035 DB09037
- Gene Ontology Go:
- external side of plasma membrane
integral component of membrane
plasma membrane
signal transducer activity
apoptotic process
humoral immune response
multicellular organism development
negative regulation of apoptotic process
negative regulation of tolerance induction
positive regulation of T cell apoptotic process
signal transduction
T cell costimulation - Gene Ontology Biological Process:
- apoptotic process
humoral immune response
multicellular organism development
negative regulation of apoptotic process
negative regulation of tolerance induction
positive regulation of T cell apoptotic process
signal transduction
T cell costimulation - Gene Ontology Molecular Function:
- signal transducer activity
- Gene Ontology Cellular Component:
- external side of plasma membrane
integral component of membrane
plasma membrane - Keywords:
- 3D-structure
Apoptosis
Complete proteome
Disulfide bond
Glycoprotein
Immunity
Immunoglobulin domain
Membrane
Polymorphism
Reference proteome
Signal
Systemic lupus erythematosus
Transmembrane
Transmembrane helix - Interacts With:
- Q9NZQ7