Names & Taxonomy
- Uniprot ID:
- Q14973
- Entry Name:
- NTCP_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium/bile acid cotransporter (Cell growth-inhibiting gene 29 protein) (Na(+)/bile acid cotransporter) (Na(+)/taurocholate transport protein) (Sodium/taurocholate cotransporting polypeptide) (Solute carrier family 10 member 1)
- Gene Names:
- SLC10A1 NTCP GIG29
- Gene Names Orf:
- GIG29
- Gene Names Primary:
- SLC10A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 349
- Sequence:
- MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKGLAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNLSIVMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSKRPQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVLSALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLLIAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.; (Microbial infection) Acts as a receptor for hepatitis B virus.
- Cross Reference Drug Bank:
- DB00887 DB02659 DB00286 DB00091 DB03619 DB00977 DB00328 DB00279 DB01583 DB08860 DB01032 DB00396 DB00624 DB01586
- Gene Ontology Go:
- basolateral plasma membrane
integral component of plasma membrane
plasma membrane
bile acid:sodium symporter activity
virus receptor activity
bile acid and bile salt transport
bile acid metabolic process
small molecule metabolic process
transport - Gene Ontology Biological Process:
- bile acid and bile salt transport
bile acid metabolic process
small molecule metabolic process
transport - Gene Ontology Molecular Function:
- bile acid:sodium symporter activity
virus receptor activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
integral component of plasma membrane
plasma membrane - Keywords:
- Complete proteome
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Ion transport
Membrane
Polymorphism
Receptor
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport