Names & Taxonomy
- Uniprot ID:
- Q14643
- Entry Name:
- ITPR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)
- Gene Names:
- ITPR1 INSP3R1
- Gene Names Primary:
- ITPR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 2758
- Sequence:
- MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYSLVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEFVEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVTTIFPISKMAKGEENKGNNDVEKLKSSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQEGPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMMTKDRGYGEKLISIDELDNAELPPAPDSENATEELEPSPPLRQLEDHKRGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEFEDGENGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQVDGDEALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLISLAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSPAPREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPPHMNVNPQQPA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Multi-pass membrane protein.
Function
- Function:
- Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
- Cross Reference Drug Bank:
- DB00201
- Gene Ontology Go:
- calcineurin complex
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
membrane
nuclear inner membrane
nucleolus
platelet dense granule membrane
platelet dense tubular network
platelet dense tubular network membrane
postsynaptic density
sarcoplasmic reticulum
calcium channel inhibitor activity
calcium ion transmembrane transporter activity
calcium-release channel activity
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
phosphatidylinositol binding
activation of phospholipase C activity
blood coagulation
calcium ion transport
cardiac conduction
endoplasmic reticulum calcium ion homeostasis
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
epithelial fluid transport
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
fibroblast growth factor receptor signaling pathway
innate immune response
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of calcium-mediated signaling
neurotrophin TRK receptor signaling pathway
platelet activation
post-embryonic development
regulation of autophagy
regulation of cardiac conduction
regulation of insulin secretion
release of sequestered calcium ion into cytosol
response to hypoxia
signal transduction
small molecule metabolic process
stimulatory C-type lectin receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
voluntary musculoskeletal movement - Gene Ontology Biological Process:
- activation of phospholipase C activity
blood coagulation
calcium ion transport
cardiac conduction
endoplasmic reticulum calcium ion homeostasis
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
epithelial fluid transport
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
fibroblast growth factor receptor signaling pathway
innate immune response
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of calcium-mediated signaling
neurotrophin TRK receptor signaling pathway
platelet activation
post-embryonic development
regulation of autophagy
regulation of cardiac conduction
regulation of insulin secretion
release of sequestered calcium ion into cytosol
response to hypoxia
signal transduction
small molecule metabolic process
stimulatory C-type lectin receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
voluntary musculoskeletal movement - Gene Ontology Molecular Function:
- calcium channel inhibitor activity
calcium ion transmembrane transporter activity
calcium-release channel activity
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
phosphatidylinositol binding - Gene Ontology Cellular Component:
- calcineurin complex
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
membrane
nuclear inner membrane
nucleolus
platelet dense granule membrane
platelet dense tubular network
platelet dense tubular network membrane
postsynaptic density
sarcoplasmic reticulum - Keywords:
- Alternative splicing
Apoptosis
Calcium
Calcium channel
Calcium transport
Complete proteome
Disease mutation
Endoplasmic reticulum
Glycoprotein
Ion channel
Ion transport
Isopeptide bond
Ligand-gated ion channel
Membrane
Neurodegeneration
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Spinocerebellar ataxia
Transmembrane
Transmembrane helix
Transport
Ubl conjugation - Interacts With:
- P21796