Names & Taxonomy
- Uniprot ID:
- Q14246
- Entry Name:
- AGRE1_HUMAN
- Status:
- reviewed
- Protein Names:
- Adhesion G protein-coupled receptor E1 (EGF-like module receptor 1) (EGF-like module-containing mucin-like hormone receptor-like 1) (EMR1 hormone receptor)
- Gene Names:
- ADGRE1 EMR1 TM7LN3
- Gene Names Primary:
- ADGRE1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 886
- Sequence:
- MRGFNLLLFWGCCVMHSWEGHIRPTRKPNTKGNNCRDSTLCPAYATCTNTVDSYYCACKQGFLSSNGQNHFKDPGVRCKDIDECSQSPQPCGPNSSCKNLSGRYKCSCLDGFSSPTGNDWVPGKPGNFSCTDINECLTSSVCPEHSDCVNSMGSYSCSCQVGFISRNSTCEDVDECADPRACPEHATCNNTVGNYSCFCNPGFESSSGHLSFQGLKASCEDIDECTEMCPINSTCTNTPGSYFCTCHPGFAPSNGQLNFTDQGVECRDIDECRQDPSTCGPNSICTNALGSYSCGCIAGFHPNPEGSQKDGNFSCQRVLFKCKEDVIPDNKQIQQCQEGTAVKPAYVSFCAQINNIFSVLDKVCENKTTVVSLKNTTESFVPVLKQISTWTKFTKEETSSLATVFLESVESMTLASFWKPSANITPAVRTEYLDIESKVINKECSEENVTLDLVAKGDKMKIGCSTIEESESTETTGVAFVSFVGMESVLNERFFKDHQAPLTTSEIKLKMNSRVVGGIMTGEKKDGFSDPIIYTLENIQPKQKFERPICVSWSTDVKGGRWTSFGCVILEASETYTICSCNQMANLAVIMASGELTMDFSLYIISHVGIIISLVCLVLAIATFLLCRSIRNHNTYLHLHLCVCLLLAKTLFLAGIHKTDNKMGCAIIAGFLHYLFLACFFWMLVEAVILFLMVRNLKVVNYFSSRNIKMLHICAFGYGLPMLVVVISASVQPQGYGMHNRCWLNTETGFIWSFLGPVCTVIVINSLLLTWTLWILRQRLSSVNAEVSTLKDTRLLTFKAFAQLFILGCSWVLGIFQIGPVAGVMAYLFTIINSLQGAFIFLIHCLLNGQVREEYKRWITGKTKPSSQSQTSRILLSSMPSASKTG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.
- Gene Ontology Go:
- external side of plasma membrane
integral component of plasma membrane
calcium ion binding
G-protein coupled receptor activity
adaptive immune response
cell adhesion
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway - Gene Ontology Biological Process:
- adaptive immune response
cell adhesion
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway - Gene Ontology Molecular Function:
- calcium ion binding
G-protein coupled receptor activity - Gene Ontology Cellular Component:
- external side of plasma membrane
integral component of plasma membrane - Keywords:
- Adaptive immunity
Alternative splicing
Calcium
Cell membrane
Complete proteome
Disulfide bond
EGF-like domain
G-protein coupled receptor
Glycoprotein
Immunity
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transducer
Transmembrane
Transmembrane helix