Names & Taxonomy

Uniprot ID:
Q14145
Entry Name:
KEAP1_HUMAN
Status:
reviewed
Protein Names:
Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19)
Gene Names:
KEAP1 INRF2 KIAA0132 KLHL19
Gene Names Primary:
KEAP1
Organism:
Homo sapiens (Human)

Structure

Length:
624
Sequence:
MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQIDQQNCTC
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.

Function

Function:
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Pathway:
Protein modification; protein ubiquitination.
Enzyme Regulation:
ENZYME REGULATION: Ubiquitination and subsequent degradation of PGAM5 is inhibited by oxidative stress and sulforaphane. Sulforaphane also inhibits ubiquitination of NFE2L2/NRF2.
Cross Reference Drug Bank:
DB08908
Gene Ontology Go:
actin filament
cell-cell adherens junction
Cul3-RING ubiquitin ligase complex
cytoplasm
cytosol
endoplasmic reticulum
focal adhesion
microtubule organizing center
midbody
nucleoplasm
transcription factor binding
alkanesulfonate metabolic process
cellular response to interleukin-4
cellular response to organic cyclic compound
cytoplasmic sequestering of transcription factor
flavonoid metabolic process
in utero embryonic development
malate metabolic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
proteasomal ubiquitin-independent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
protein oligomerization
protein ubiquitination
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of epidermal cell differentiation
response to immobilization stress
response to metal ion
response to thyroid hormone
selenium compound metabolic process
transcription, DNA-templated
Gene Ontology Biological Process:
alkanesulfonate metabolic process
cellular response to interleukin-4
cellular response to organic cyclic compound
cytoplasmic sequestering of transcription factor
flavonoid metabolic process
in utero embryonic development
malate metabolic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
proteasomal ubiquitin-independent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
protein oligomerization
protein ubiquitination
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of epidermal cell differentiation
response to immobilization stress
response to metal ion
response to thyroid hormone
selenium compound metabolic process
transcription, DNA-templated
Gene Ontology Molecular Function:
transcription factor binding
Gene Ontology Cellular Component:
actin filament
cell-cell adherens junction
Cul3-RING ubiquitin ligase complex
cytoplasm
cytosol
endoplasmic reticulum
focal adhesion
microtubule organizing center
midbody
nucleoplasm
Keywords:
3D-structure
Complete proteome
Cytoplasm
Kelch repeat
Nucleus
Polymorphism
Reference proteome
Repeat
Transcription
Transcription regulation
Ubl conjugation
Ubl conjugation pathway
Interacts With:
A9UGY9; Q9NPC3; Q9NY33; P62495; Q6P1L5; Q14440; B8Q183; O14920; O88351; P15314; Q8N4I8; P62310; Q13257; O60336; Q16236; Q9NZJ9; Q8N573-5; P54619; P06454-2; Q6P9E2; Q04206; Q13501; Q64337; P54274; Q9Y3Q8; Q9BRX9; I3L3J2

Publication

PubMed ID:
8590280 14702039 15057824 15489334 14585973 15379550 15572695 15983046 15657435 16687406 17046835 18387606 19424503 21269460 24089205 15583386 16204884 16888629 16507366 17020408 16959974