Names & Taxonomy
- Uniprot ID:
- Q14126
- Entry Name:
- DSG2_HUMAN
- Status:
- reviewed
- Protein Names:
- Desmoglein-2 (Cadherin family member 5) (HDGC)
- Gene Names:
- DSG2 CDHF5
- Gene Names Primary:
- DSG2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1118
- Sequence:
- MARSPGRAYALLLLLICFNVGSGLHLQVLSTRNENKLLPKHPHLVRQKRAWITAPVALREGEDLSKKNPIAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGYALDARGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDADEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGEVTDKPVKQAQVQIRILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPGMAEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVGLGPAAIALMILAFLLLLLVPLLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGRWEEHRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVYSQEETESLNASIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATETSMNTASHSLCEQTMVNSENTYSSGSSFPVPKSLQEANAEKVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVYAPASTLVDQPYANEGTVVVTERVIQPHGGGSNPLEGTQHLQDVPYVMVRERESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTENSMTARNTTVSGAGVPGPLPDFGLEESGHSNSTITTSSTRVTKHSTVQHSYS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Function
- Function:
- Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
- Gene Ontology Go:
- apical plasma membrane
cell surface
cell-cell junction
desmosome
extracellular exosome
integral component of membrane
intercalated disc
lateral plasma membrane
plasma membrane
calcium ion binding
cell adhesion molecule binding
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
apoptotic process
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
cell adhesion
cellular component disassembly involved in execution phase of apoptosis
desmosome organization
homophilic cell adhesion via plasma membrane adhesion molecules
maternal process involved in female pregnancy
programmed cell death
Purkinje myocyte development
regulation of heart rate by cardiac conduction
regulation of ventricular cardiac muscle cell action potential
response to progesterone - Gene Ontology Biological Process:
- apoptotic process
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
cell adhesion
cellular component disassembly involved in execution phase of apoptosis
desmosome organization
homophilic cell adhesion via plasma membrane adhesion molecules
maternal process involved in female pregnancy
programmed cell death
Purkinje myocyte development
regulation of heart rate by cardiac conduction
regulation of ventricular cardiac muscle cell action potential
response to progesterone - Gene Ontology Molecular Function:
- calcium ion binding
cell adhesion molecule binding
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication - Gene Ontology Cellular Component:
- apical plasma membrane
cell-cell junction
cell surface
desmosome
extracellular exosome
integral component of membrane
intercalated disc
lateral plasma membrane
plasma membrane - Keywords:
- 3D-structure
Calcium
Cardiomyopathy
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Disease mutation
Glycoprotein
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix