Names & Taxonomy

Uniprot ID:
Q14123
Entry Name:
PDE1C_HUMAN
Status:
reviewed
Protein Names:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17) (hCam-3)
Gene Names:
PDE1C
Gene Names Primary:
PDE1C
Organism:
Homo sapiens (Human)

Structure

Length:
709
Sequence:
MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAKRSGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKARLAAEEQQKEMEAKSQAEEGASGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSGEQQQNGDFKDGKNKTDKKDHSNIGNDSKKTDGTKQRSHGSPAPSTSSTCRLTLPVIKPPLRHFKRPAYASSSYAPSVSKKTDEHPARYKMLDQRIKMKKIQNISHNWNRK
Proteomes:
UP000005640

Function

Function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.
Catalytic Activity:
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
Cofactor:
COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
Enzyme Regulation:
ENZYME REGULATION: Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+).
Active Site:
ACT_SITE 228 228 Proton donor.
Cross Reference Drug Bank:
DB00201
Gene Ontology Go:
cytosol
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
metal ion binding
activation of phospholipase C activity
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
neurotrophin TRK receptor signaling pathway
signal transduction
Gene Ontology Biological Process:
activation of phospholipase C activity
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
neurotrophin TRK receptor signaling pathway
signal transduction
Gene Ontology Molecular Function:
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
metal ion binding
Gene Ontology Cellular Component:
cytosol
Keywords:
3D-structure
Acetylation
Alternative splicing
Calmodulin-binding
Complete proteome
Hydrolase
Metal-binding
Reference proteome
cAMP
cGMP

Publication

PubMed ID:
8557689 14702039 12853948 19369195