Names & Taxonomy
- Uniprot ID:
- Q13946
- Entry Name:
- PDE7A_HUMAN
- Status:
- reviewed
- Protein Names:
- High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.53) (HCP1) (TM22)
- Gene Names:
- PDE7A
- Gene Names Primary:
- PDE7A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 482
- Sequence:
- MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform PDE7A1: Cytoplasm, cytosol. Note=PDE7A1 (57 kDa) is located mostly to soluble cellular fractions.; Isoform PDE7A2: Cytoplasm. Note=PDE7A2 (50 kDa) is located to particulate cellular fractions.
Function
- Function:
- Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.
- Pathway:
- Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
- Catalytic Activity:
- Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.
- Cofactor:
- COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Enzyme Regulation:
- ENZYME REGULATION: Insensitive to all selective PDE inhibitors.
- Active Site:
- ACT_SITE 212 212 Proton donor.
- Cross Reference Drug Bank:
- DB00201 DB00651 DB00920
- Gene Ontology Go:
- cytosol
3',5'-cyclic-AMP phosphodiesterase activity
metal ion binding
cAMP catabolic process
cAMP-mediated signaling - Gene Ontology Biological Process:
- cAMP catabolic process
cAMP-mediated signaling - Gene Ontology Molecular Function:
- 3',5'-cyclic-AMP phosphodiesterase activity
metal ion binding - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Hydrolase
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
cAMP