Names & Taxonomy
- Uniprot ID:
- Q13907
- Entry Name:
- IDI1_HUMAN
- Status:
- reviewed
- Protein Names:
- Isopentenyl-diphosphate Delta-isomerase 1 (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase 1) (IPP isomerase 1) (IPPI1)
- Gene Names:
- IDI1
- Gene Names Primary:
- IDI1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 227
- Sequence:
- MPEINTNHLDKQQVQLLAEMCILIDENDNKIGAETKKNCHLNENIEKGLLHRAFSVFLFNTENKLLLQQRSDAKITFPGCFTNTCCSHPLSNPAELEESDALGVRRAAQRRLKAELGIPLEEVPPEEINYLTRIHYKAQSDGIWGEHEIDYILLVRKNVTLNPDPNEIKSYCYVSKEELKELLKKAASGEIKITPWFKIIAATFLFKWWDNLNHLNQFVDHEKIYRM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Peroxisome.
Function
- Function:
- Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
- Pathway:
- Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.
- Catalytic Activity:
- Isopentenyl diphosphate = dimethylallyl diphosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 86 86; ACT_SITE 148 148
- Gene Ontology Go:
- cytosol
peroxisome
hydrolase activity
isopentenyl-diphosphate delta-isomerase activity
magnesium ion binding
manganese ion binding
metal ion binding
cholesterol biosynthetic process
dimethylallyl diphosphate biosynthetic process
isoprenoid biosynthetic process
small molecule metabolic process - Gene Ontology Biological Process:
- cholesterol biosynthetic process
dimethylallyl diphosphate biosynthetic process
isoprenoid biosynthetic process
small molecule metabolic process - Gene Ontology Molecular Function:
- hydrolase activity
isopentenyl-diphosphate delta-isomerase activity
magnesium ion binding
manganese ion binding
metal ion binding - Gene Ontology Cellular Component:
- cytosol
peroxisome - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Cholesterol biosynthesis
Cholesterol metabolism
Complete proteome
Isomerase
Isoprene biosynthesis
Lipid biosynthesis
Lipid metabolism
Magnesium
Metal-binding
Peroxisome
Reference proteome
Steroid biosynthesis
Steroid metabolism
Sterol biosynthesis
Sterol metabolism