Names & Taxonomy
- Uniprot ID:
- Q13873
- Entry Name:
- BMPR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
- Gene Names:
- BMPR2 PPH1
- Gene Names Primary:
- BMPR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1038
- Sequence:
- MTSSLQRPWRVPWLPWTILLVSTAAASQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRKQGLHSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTIGEKNRNSINYERQQAQARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDETNLHTTNVAQSIGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEATGQQDFTQTANGQACLIPDVLPTQIYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGSKHKSNLKQVETGVAKMNTINAAEPHVVTVTMNGVAGRNHSVNSHAATTQYANGTVLSGQTTNIVTHRAQEMLQNQFIGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQDVLAQGVPSTAADPGPSKPRRAQRPNSLDLSATNVLDGSSIQIGESTQDGKSGSGEKIKKRVKTPYSLKRWRPSTWVISTESLDCEVNNNGSNRAVHSKSSTAVYLAEGGTATTMVSKDIGMNCL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
- Catalytic Activity:
- ATP + = ADP + phosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 333 333 Proton acceptor.
- Gene Ontology Go:
- apical plasma membrane
basal plasma membrane
caveola
cell surface
cytoplasm
dendrite
extracellular space
integral component of plasma membrane
neuronal cell body
neuronal postsynaptic density
plasma membrane
spanning component of plasma membrane
activin receptor activity, type II
ATP binding
BMP binding
BMP receptor activity
metal ion binding
receptor signaling protein serine/threonine kinase activity
activin receptor signaling pathway
anterior/posterior pattern specification
artery development
blood vessel remodeling
BMP signaling pathway
brain development
cellular response to BMP stimulus
cellular response to starvation
chondrocyte development
endochondral bone morphogenesis
endothelial cell apoptotic process
endothelial cell proliferation
limb development
lung alveolus development
lymphangiogenesis
lymphatic endothelial cell differentiation
maternal placenta development
mesoderm formation
negative regulation of cell growth
negative regulation of chondrocyte proliferation
negative regulation of DNA biosynthetic process
negative regulation of systemic arterial blood pressure
negative regulation of vasoconstriction
positive regulation of axon extension involved in axon guidance
positive regulation of BMP signaling pathway
positive regulation of bone mineralization
positive regulation of cartilage development
positive regulation of endothelial cell migration
positive regulation of endothelial cell proliferation
positive regulation of epithelial cell migration
positive regulation of osteoblast differentiation
positive regulation of pathway-restricted SMAD protein phosphorylation
positive regulation of transcription from RNA polymerase II promoter
proteoglycan biosynthetic process
regulation of cell proliferation
regulation of lung blood pressure
retina vasculature development in camera-type eye
transcription from RNA polymerase II promoter
transmembrane receptor protein serine/threonine kinase signaling pathway
vascular endothelial growth factor receptor signaling pathway
venous blood vessel development - Gene Ontology Biological Process:
- activin receptor signaling pathway
anterior/posterior pattern specification
artery development
blood vessel remodeling
BMP signaling pathway
brain development
cellular response to BMP stimulus
cellular response to starvation
chondrocyte development
endochondral bone morphogenesis
endothelial cell apoptotic process
endothelial cell proliferation
limb development
lung alveolus development
lymphangiogenesis
lymphatic endothelial cell differentiation
maternal placenta development
mesoderm formation
negative regulation of cell growth
negative regulation of chondrocyte proliferation
negative regulation of DNA biosynthetic process
negative regulation of systemic arterial blood pressure
negative regulation of vasoconstriction
positive regulation of axon extension involved in axon guidance
positive regulation of BMP signaling pathway
positive regulation of bone mineralization
positive regulation of cartilage development
positive regulation of endothelial cell migration
positive regulation of endothelial cell proliferation
positive regulation of epithelial cell migration
positive regulation of osteoblast differentiation
positive regulation of pathway-restricted SMAD protein phosphorylation
positive regulation of transcription from RNA polymerase II promoter
proteoglycan biosynthetic process
regulation of cell proliferation
regulation of lung blood pressure
retina vasculature development in camera-type eye
transcription from RNA polymerase II promoter
transmembrane receptor protein serine/threonine kinase signaling pathway
vascular endothelial growth factor receptor signaling pathway
venous blood vessel development - Gene Ontology Molecular Function:
- activin receptor activity, type II
ATP binding
BMP binding
BMP receptor activity
metal ion binding
receptor signaling protein serine/threonine kinase activity - Gene Ontology Cellular Component:
- apical plasma membrane
basal plasma membrane
caveola
cell surface
cytoplasm
dendrite
extracellular space
integral component of plasma membrane
neuronal cell body
neuronal postsynaptic density
plasma membrane
spanning component of plasma membrane - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Kinase
Magnesium
Manganese
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Serine/threonine-protein kinase
Signal
Transferase
Transmembrane
Transmembrane helix - Interacts With:
- P08607; P43026; P68404; Q13976