Names & Taxonomy

Uniprot ID:
Q13733
Entry Name:
AT1A4_HUMAN
Status:
reviewed
Protein Names:
Sodium/potassium-transporting ATPase subunit alpha-4 (Na(+)/K(+) ATPase alpha-4 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-4)
Gene Names:
ATP1A4 ATP1AL2
Gene Names Primary:
ATP1A4
Organism:
Homo sapiens (Human)

Structure

Length:
1029
Sequence:
MGLWGKKGTVAPHDQSPRRRPKKGLIKKKMVKREKQKRNMEELKKEVVMDDHKLTLEELSTKYSVDLTKGHSHQRAKEILTRGGPNTVTPPPTTPEWVKFCKQLFGGFSLLLWTGAILCFVAYSIQIYFNEEPTKDNLYLSIVLSVVVIVTGCFSYYQEAKSSKIMESFKNMVPQQALVIRGGEKMQINVQEVVLGDLVEIKGGDRVPADLRLISAQGCKVDNSSLTGESEPQSRSPDFTHENPLETRNICFFSTNCVEGTARGIVIATGDSTVMGRIASLTSGLAVGQTPIAAEIEHFIHLITVVAVFLGVTFFALSLLLGYGWLEAIIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDMTVYEADTTEEQTGKTFTKSSDTWFMLARIAGLCNRADFKANQEILPIAKRATTGDASESALLKFIEQSYSSVAEMREKNPKVAEIPFNSTNKYQMSIHLREDSSQTHVLMMKGAPERILEFCSTFLLNGQEYSMNDEMKEAFQNAYLELGGLGERVLGFCFLNLPSSFSKGFPFNTDEINFPMDNLCFVGLISMIDPPRAAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGTETAEEVAARLKIPISKVDASAAKAIVVHGAELKDIQSKQLDQILQNHPEIVFARTSPQQKLIIVEGCQRLGAVVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIMYTLTSNIPEITPFLMFIILGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKRLPRNPKTDNLVNHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPVDLLGIRLHWEDKYLNDLEDSYGQQWTYEQRKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVLIFGILEETLLAAFLSYTPGMDVALRMYPLKITWWLCAIPYSILIFVYDEIRKLLIRQHPDGWVERETYY
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.
Catalytic Activity:
ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In).
Enzyme Regulation:
ENZYME REGULATION: Specifically inhibited by an endogenous cardiac glycoside, ouabain.
Active Site:
ACT_SITE 384 384 4-aspartylphosphate intermediate.
Gene Ontology Go:
integral component of plasma membrane
intracellular membrane-bounded organelle
plasma membrane
sodium:potassium-exchanging ATPase complex
ATP binding
metal ion binding
sodium:potassium-exchanging ATPase activity
ATP hydrolysis coupled proton transport
cardiac conduction
cellular potassium ion homeostasis
cellular sodium ion homeostasis
fertilization
ion transmembrane transport
potassium ion import
potassium ion transport
regulation of cardiac conduction
regulation of cellular pH
regulation of membrane potential
sodium ion export from cell
sodium ion transport
sperm motility
spermatogenesis
transmembrane transport
Gene Ontology Biological Process:
ATP hydrolysis coupled proton transport
cardiac conduction
cellular potassium ion homeostasis
cellular sodium ion homeostasis
fertilization
ion transmembrane transport
potassium ion import
potassium ion transport
regulation of cardiac conduction
regulation of cellular pH
regulation of membrane potential
sodium ion export from cell
sodium ion transport
spermatogenesis
sperm motility
transmembrane transport
Gene Ontology Molecular Function:
ATP binding
metal ion binding
sodium:potassium-exchanging ATPase activity
Gene Ontology Cellular Component:
integral component of plasma membrane
intracellular membrane-bounded organelle
plasma membrane
sodium:potassium-exchanging ATPase complex
Keywords:
ATP-binding
Alternative splicing
Cell membrane
Complete proteome
Hydrolase
Ion transport
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Potassium
Potassium transport
Reference proteome
Sodium
Sodium transport
Sodium/potassium transport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
16175638 16710414 15489334 12119109 7809153 14702039