Names & Taxonomy
- Uniprot ID:
- Q13724
- Entry Name:
- MOGS_HUMAN
- Status:
- reviewed
- Protein Names:
- Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Processing A-glucosidase I)
- Gene Names:
- MOGS GCS1
- Gene Names Primary:
- MOGS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 837
- Sequence:
- MARGERRRRAVPAEGVRTAERAARGGPGRRDGRGGGPRSTAGGVALAVVVLSLALGMSGRWVLAWYRARRAVTLHSAPPVLPADSSSPAVAPDLFWGTYRPHVYFGMKTRSPKPLLTGLMWAQQGTTPGTPKLRHTCEQGDGVGPYGWEFHDGLSFGRQHIQDGALRLTTEFVKRPGGQHGGDWSWRVTVEPQDSGTSALPLVSLFFYVVTDGKEVLLPEVGAKGQLKFISGHTSELGDFRFTLLPPTSPGDTAPKYGSYNVFWTSNPGLPLLTEMVKSRLNSWFQHRPPGAPPERYLGLPGSLKWEDRGPSGQGQGQFLIQQVTLKIPISIEFVFESGSAQAGGNQALPRLAGSLLTQALESHAEGFRERFEKTFQLKEKGLSSGEQVLGQAALSGLLGGIGYFYGQGLVLPDIGVEGSEQKVDPALFPPVPLFTAVPSRSFFPRGFLWDEGFHQLVVQRWDPSLTREALGHWLGLLNADGWIGREQILGDEARARVPPEFLVQRAVHANPPTLLLPVAHMLEVGDPDDLAFLRKALPRLHAWFSWLHQSQAGPLPLSYRWRGRDPALPTLLNPKTLPSGLDDYPRASHPSVTERHLDLRCWVALGARVLTRLAEHLGEAEVAAELGPLAASLEAAESLDELHWAPELGVFADFGNHTKAVQLKPRPPQGLVRVVGRPQPQLQYVDALGYVSLFPLLLRLLDPTSSRLGPLLDILADSRHLWSPFGLRSLAASSSFYGQRNSEHDPPYWRGAVWLNVNYLALGALHHYGHLEGPHQARAAKLHGELRANVVGNVWRQYQATGFLWEQYSDRDGRGMGCRPFHGWTSLVLLAMAEDY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Function
- Function:
- Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner.
- Pathway:
- Glycan metabolism; N-glycan degradation.
- Catalytic Activity:
- Exohydrolysis of the non-reducing terminal glucose residues in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2).
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
integral component of membrane
membrane
glucosidase activity
mannosyl-oligosaccharide glucosidase activity
cellular protein metabolic process
oligosaccharide metabolic process
post-translational protein modification
protein folding
protein N-linked glycosylation
protein N-linked glycosylation via asparagine - Gene Ontology Biological Process:
- cellular protein metabolic process
oligosaccharide metabolic process
post-translational protein modification
protein folding
protein N-linked glycosylation
protein N-linked glycosylation via asparagine - Gene Ontology Molecular Function:
- glucosidase activity
mannosyl-oligosaccharide glucosidase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
integral component of membrane
membrane - Keywords:
- Alternative splicing
Complete proteome
Disease mutation
Endoplasmic reticulum
Glycoprotein
Glycosidase
Hydrolase
Membrane
Polymorphism
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix