Names & Taxonomy

Uniprot ID:
Q13627
Entry Name:
DYR1A_HUMAN
Status:
reviewed
Protein Names:
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene Names:
DYRK1A DYRK MNB MNBH
Gene Names Primary:
DYRK1A
Organism:
Homo sapiens (Human)

Structure

Length:
763
Sequence:
MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus speckle.

Function

Function:
May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3.
Catalytic Activity:
ATP + a protein = ADP + a phosphoprotein.
Enzyme Regulation:
ENZYME REGULATION: Inhibited by RANBP9. Inhibited by harmine, leucettamine B and leucettine L41.
Active Site:
ACT_SITE 287 287 Proton acceptor.
Gene Ontology Go:
intracellular ribonucleoprotein complex
nuclear speck
nucleoplasm
nucleus
ATP binding
non-membrane spanning protein tyrosine kinase activity
protein kinase activity
protein self-association
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
tau protein binding
circadian rhythm
mitotic cell cycle
negative regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of mRNA splicing, via spliceosome
nervous system development
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
peptidyl-tyrosine phosphorylation
positive regulation of protein deacetylation
protein autophosphorylation
protein phosphorylation
regulation of alternative mRNA splicing, via spliceosome
Gene Ontology Biological Process:
circadian rhythm
mitotic cell cycle
negative regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of mRNA splicing, via spliceosome
nervous system development
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
peptidyl-tyrosine phosphorylation
positive regulation of protein deacetylation
protein autophosphorylation
protein phosphorylation
regulation of alternative mRNA splicing, via spliceosome
Gene Ontology Molecular Function:
ATP binding
non-membrane spanning protein tyrosine kinase activity
protein kinase activity
protein self-association
protein serine/threonine/tyrosine kinase activity
protein serine/threonine kinase activity
protein tyrosine kinase activity
tau protein binding
Gene Ontology Cellular Component:
intracellular ribonucleoprotein complex
nuclear speck
nucleoplasm
nucleus
Keywords:
3D-structure
ATP-binding
Alternative splicing
Complete proteome
Kinase
Mental retardation
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase
Tyrosine-protein kinase
Interacts With:
P61962; Q9BRK4; P06400; P28749; Q12815; P31946

Publication

PubMed ID:
8975710 8872470 8769099 9037601 10329007 9503011 14500717 14593110 15592455 18691976 19266028 19690332 21294719 21127067 22767602 23864635 24275569 20981014 22998443 24239188 23665168 17344846