Names & Taxonomy
- Uniprot ID:
- Q13627
- Entry Name:
- DYR1A_HUMAN
- Status:
- reviewed
- Protein Names:
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
- Gene Names:
- DYRK1A DYRK MNB MNBH
- Gene Names Primary:
- DYRK1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 763
- Sequence:
- MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus speckle.
Function
- Function:
- May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3.
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by RANBP9. Inhibited by harmine, leucettamine B and leucettine L41.
- Active Site:
- ACT_SITE 287 287 Proton acceptor.
- Gene Ontology Go:
- intracellular ribonucleoprotein complex
nuclear speck
nucleoplasm
nucleus
ATP binding
non-membrane spanning protein tyrosine kinase activity
protein kinase activity
protein self-association
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
tau protein binding
circadian rhythm
mitotic cell cycle
negative regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of mRNA splicing, via spliceosome
nervous system development
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
peptidyl-tyrosine phosphorylation
positive regulation of protein deacetylation
protein autophosphorylation
protein phosphorylation
regulation of alternative mRNA splicing, via spliceosome - Gene Ontology Biological Process:
- circadian rhythm
mitotic cell cycle
negative regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of mRNA splicing, via spliceosome
nervous system development
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
peptidyl-tyrosine phosphorylation
positive regulation of protein deacetylation
protein autophosphorylation
protein phosphorylation
regulation of alternative mRNA splicing, via spliceosome - Gene Ontology Molecular Function:
- ATP binding
non-membrane spanning protein tyrosine kinase activity
protein kinase activity
protein self-association
protein serine/threonine/tyrosine kinase activity
protein serine/threonine kinase activity
protein tyrosine kinase activity
tau protein binding - Gene Ontology Cellular Component:
- intracellular ribonucleoprotein complex
nuclear speck
nucleoplasm
nucleus - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Complete proteome
Kinase
Mental retardation
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase
Tyrosine-protein kinase - Interacts With:
- P61962; Q9BRK4; P06400; P28749; Q12815; P31946