Names & Taxonomy

Uniprot ID:
Q13530
Entry Name:
SERC3_HUMAN
Status:
reviewed
Protein Names:
Serine incorporator 3 (Tumor differentially expressed protein 1)
Gene Names:
SERINC3 DIFF33 TDE1 SBBI99
Gene Names Orf:
SBBI99
Gene Names Primary:
SERINC3
Organism:
Homo sapiens (Human)

Structure

Length:
473
Sequence:
MGAVLGVFSLASWVPCLCSGASCLLCSCCPNSKNSTVTRLIYAFILLLSTVVSYIMQRKEMETYLKKIPGFCEGGFKIHEADINADKDCDVLVGYKAVYRISFAMAIFFFVFSLLMFKVKTSKDLRAAVHNGFWFFKIAALIGIMVGSFYIPGGYFSSVWFVVGMIGAALFILIQLVLLVDFAHSWNESWVNRMEEGNPRLWYAALLSFTSAFYILSIICVGLLYTYYTKPDGCTENKFFISINLILCVVASIISIHPKIQEHQPRSGLLQSSLITLYTMYLTWSAMSNEPDRSCNPNLMSFITRITAPTLAPGNSTAVVPTPTPPSKSGSLLDSDNFIGLFVFVLCLLYSSIRTSTNSQVDKLTLSGSDSVILGDTTTSGASDEEDGQPRRAVDNEKEGVQYSYSLFHLMLCLASLYIMMTLTSWYSPDAKFQSMTSKWPAVWVKISSSWVCLLLYVWTLVAPLVLTSRDFS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734).
Gene Ontology Go:
Golgi membrane
integral component of membrane
plasma membrane
L-serine transmembrane transporter activity
defense response to virus
detection of virus
innate immune response
phosphatidylserine metabolic process
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
sphingolipid metabolic process
Gene Ontology Biological Process:
defense response to virus
detection of virus
innate immune response
phosphatidylserine metabolic process
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
sphingolipid metabolic process
Gene Ontology Molecular Function:
L-serine transmembrane transporter activity
Gene Ontology Cellular Component:
Golgi membrane
integral component of membrane
plasma membrane
Keywords:
Alternative splicing
Antiviral defense
Cell membrane
Complete proteome
Cytoplasm
Glycoprotein
Golgi apparatus
Immunity
Innate immunity
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

Publication

PubMed ID:
10559794 14702039 11780052 15489334 26416733 26416734