Names & Taxonomy
- Uniprot ID:
- Q13530
- Entry Name:
- SERC3_HUMAN
- Status:
- reviewed
- Protein Names:
- Serine incorporator 3 (Tumor differentially expressed protein 1)
- Gene Names:
- SERINC3 DIFF33 TDE1 SBBI99
- Gene Names Orf:
- SBBI99
- Gene Names Primary:
- SERINC3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 473
- Sequence:
- MGAVLGVFSLASWVPCLCSGASCLLCSCCPNSKNSTVTRLIYAFILLLSTVVSYIMQRKEMETYLKKIPGFCEGGFKIHEADINADKDCDVLVGYKAVYRISFAMAIFFFVFSLLMFKVKTSKDLRAAVHNGFWFFKIAALIGIMVGSFYIPGGYFSSVWFVVGMIGAALFILIQLVLLVDFAHSWNESWVNRMEEGNPRLWYAALLSFTSAFYILSIICVGLLYTYYTKPDGCTENKFFISINLILCVVASIISIHPKIQEHQPRSGLLQSSLITLYTMYLTWSAMSNEPDRSCNPNLMSFITRITAPTLAPGNSTAVVPTPTPPSKSGSLLDSDNFIGLFVFVLCLLYSSIRTSTNSQVDKLTLSGSDSVILGDTTTSGASDEEDGQPRRAVDNEKEGVQYSYSLFHLMLCLASLYIMMTLTSWYSPDAKFQSMTSKWPAVWVKISSSWVCLLLYVWTLVAPLVLTSRDFS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734).
- Gene Ontology Go:
- Golgi membrane
integral component of membrane
plasma membrane
L-serine transmembrane transporter activity
defense response to virus
detection of virus
innate immune response
phosphatidylserine metabolic process
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
sphingolipid metabolic process - Gene Ontology Biological Process:
- defense response to virus
detection of virus
innate immune response
phosphatidylserine metabolic process
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
sphingolipid metabolic process - Gene Ontology Molecular Function:
- L-serine transmembrane transporter activity
- Gene Ontology Cellular Component:
- Golgi membrane
integral component of membrane
plasma membrane - Keywords:
- Alternative splicing
Antiviral defense
Cell membrane
Complete proteome
Cytoplasm
Glycoprotein
Golgi apparatus
Immunity
Innate immunity
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix