Names & Taxonomy

Uniprot ID:
Q13526
Entry Name:
PIN1_HUMAN
Status:
reviewed
Protein Names:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1)
Gene Names:
PIN1
Gene Names Primary:
PIN1
Organism:
Homo sapiens (Human)

Structure

Length:
163
Sequence:
MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus

Function

Function:
Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins (PubMed:21497122, PubMed:22033920). Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923).
Catalytic Activity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
Gene Ontology Go:
cytosol
midbody
mitochondrion
neuron projection
nuclear speck
nucleoplasm
nucleus
beta-catenin binding
GTPase activating protein binding
mitogen-activated protein kinase kinase binding
motor activity
peptidyl-prolyl cis-trans isomerase activity
phosphoserine binding
phosphothreonine binding
cell cycle
cytokine-mediated signaling pathway
innate immune response
negative regulation of cell motility
negative regulation of ERK1 and ERK2 cascade
negative regulation of neuron apoptotic process
negative regulation of protein binding
negative regulation of protein catabolic process
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of type I interferon production
neuron differentiation
positive regulation of canonical Wnt signaling pathway
positive regulation of cell growth involved in cardiac muscle cell development
positive regulation of GTPase activity
positive regulation of neuron apoptotic process
positive regulation of protein dephosphorylation
positive regulation of protein phosphorylation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of ubiquitin-protein transferase activity
protein peptidyl-prolyl isomerization
protein stabilization
regulation of cytokinesis
regulation of mitotic nuclear division
regulation of pathway-restricted SMAD protein phosphorylation
regulation of protein localization to nucleus
synapse organization
Gene Ontology Biological Process:
cell cycle
cytokine-mediated signaling pathway
innate immune response
negative regulation of cell motility
negative regulation of ERK1 and ERK2 cascade
negative regulation of neuron apoptotic process
negative regulation of protein binding
negative regulation of protein catabolic process
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of type I interferon production
neuron differentiation
positive regulation of canonical Wnt signaling pathway
positive regulation of cell growth involved in cardiac muscle cell development
positive regulation of GTPase activity
positive regulation of neuron apoptotic process
positive regulation of protein dephosphorylation
positive regulation of protein phosphorylation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of ubiquitin-protein transferase activity
protein peptidyl-prolyl isomerization
protein stabilization
regulation of cytokinesis
regulation of mitotic nuclear division
regulation of pathway-restricted SMAD protein phosphorylation
regulation of protein localization to nucleus
synapse organization
Gene Ontology Molecular Function:
beta-catenin binding
GTPase activating protein binding
mitogen-activated protein kinase kinase binding
motor activity
peptidyl-prolyl cis-trans isomerase activity
phosphoserine binding
phosphothreonine binding
Gene Ontology Cellular Component:
cytosol
midbody
mitochondrion
neuron projection
nuclear speck
nucleoplasm
nucleus
Keywords:
3D-structure
Acetylation
Cell cycle
Complete proteome
Cytoplasm
Isomerase
Nucleus
Phosphoprotein
Reference proteome
Rotamase
Interacts With:
Q9NYB9; Q6UY14-3; P78563; Q4VCS5-2; Q6AI12; P05067-4; P85298-4; D3DTR7; P35520; Q52MB2; Q15131; D3DR37; Q8TAP6; Q969H4; O75553; O15409; Q08379; P31424-2; Q3UVX5; Q96MH2; Q8IX15-3; Q13422; Q9UKT9; P51617; Q96AA8; Q15323; O76015; Q6A162; P60409; P60411; Q9BYR5; P31938; Q63932; P41279; Q99750; A4D127; Q5JR59; Q15742; Q9HC98; Q15233; Q15233-2; P46531; P37198; Q8ND90; Q96M27; Q7Z5J4; Q99708-2; Q93062; Q13950; Q13342; Q8NA61; Q9BWW4; Q9BR01; Q8N5C8; P15884; Q9BT49; Q15025; P04637; Q13077; Q12933; Q15654; Q9Y3Q8; O43829; O15209; O15156; Q96C00; Q8NF64; Q8NF64-2; Q96AF5

Publication

PubMed ID:
8606777 14702039 15489334 11470801 15664191 16476580 16644721 17828269 17525332 18628984 19367327 19608861 21269460 22033920 21497122 22608923 9200606