Names & Taxonomy
- Uniprot ID:
- Q13507
- Entry Name:
- TRPC3_HUMAN
- Status:
- reviewed
- Protein Names:
- Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (TRP-3) (hTrp-3) (hTrp3)
- Gene Names:
- TRPC3 TRP3
- Gene Names Primary:
- TRPC3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 836
- Sequence:
- MREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSMLRCE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
calcium channel activity
inositol 1,4,5 trisphosphate binding
store-operated calcium channel activity
axon guidance
blood coagulation
calcium ion transmembrane transport
calcium ion transport
ion transmembrane transport
manganese ion transport
phototransduction
platelet activation
positive regulation of calcium ion transport into cytosol
positive regulation of cardiac muscle hypertrophy in response to stress
regulation of cytosolic calcium ion concentration
response to ATP
response to calcium ion
single fertilization
transmembrane transport - Gene Ontology Biological Process:
- axon guidance
blood coagulation
calcium ion transmembrane transport
calcium ion transport
ion transmembrane transport
manganese ion transport
phototransduction
platelet activation
positive regulation of calcium ion transport into cytosol
positive regulation of cardiac muscle hypertrophy in response to stress
regulation of cytosolic calcium ion concentration
response to ATP
response to calcium ion
single fertilization
transmembrane transport - Gene Ontology Molecular Function:
- calcium channel activity
inositol 1,4,5 trisphosphate binding
store-operated calcium channel activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- ANK repeat
Alternative splicing
Calcium
Calcium channel
Calcium transport
Complete proteome
Disease mutation
Glycoprotein
Ion channel
Ion transport
Membrane
Neurodegeneration
Reference proteome
Repeat
Spinocerebellar ataxia
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q14573; P20591; P10686