Names & Taxonomy
- Uniprot ID:
- Q13443
- Entry Name:
- ADAM9_HUMAN
- Status:
- reviewed
- Protein Names:
- Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase)
- Gene Names:
- ADAM9 KIAA0021 MCMP MDC9 MLTNG
- Gene Names Primary:
- ADAM9
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 819
- Sequence:
- MGSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAAKQPQQFPSRPPPPQPKVSSQGNLIPARPAPAPPLYSSLT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane
Function
- Function:
- Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase activity for APP.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 348 348
- Gene Ontology Go:
- cell surface
extracellular exosome
extracellular space
focal adhesion
integral component of membrane
intrinsic component of external side of plasma membrane
collagen binding
integrin binding
laminin binding
metalloendopeptidase activity
metallopeptidase activity
protein kinase C binding
SH3 domain binding
zinc ion binding
activation of MAPKK activity
cell adhesion
cell adhesion mediated by integrin
cell-cell adhesion mediated by integrin
cell-matrix adhesion
cellular response to lipopolysaccharide
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
integrin-mediated signaling pathway
keratinocyte differentiation
membrane protein ectodomain proteolysis
monocyte activation
PMA-inducible membrane protein ectodomain proteolysis
positive regulation of cell adhesion mediated by integrin
positive regulation of keratinocyte migration
positive regulation of macrophage fusion
positive regulation of membrane protein ectodomain proteolysis
positive regulation of protein secretion
response to calcium ion
response to glucocorticoid
response to hydrogen peroxide
response to manganese ion
response to tumor necrosis factor
transforming growth factor beta receptor signaling pathway - Gene Ontology Biological Process:
- activation of MAPKK activity
cell adhesion
cell adhesion mediated by integrin
cell-cell adhesion mediated by integrin
cell-matrix adhesion
cellular response to lipopolysaccharide
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
integrin-mediated signaling pathway
keratinocyte differentiation
membrane protein ectodomain proteolysis
monocyte activation
PMA-inducible membrane protein ectodomain proteolysis
positive regulation of cell adhesion mediated by integrin
positive regulation of keratinocyte migration
positive regulation of macrophage fusion
positive regulation of membrane protein ectodomain proteolysis
positive regulation of protein secretion
response to calcium ion
response to glucocorticoid
response to hydrogen peroxide
response to manganese ion
response to tumor necrosis factor
transforming growth factor beta receptor signaling pathway - Gene Ontology Molecular Function:
- collagen binding
integrin binding
laminin binding
metalloendopeptidase activity
metallopeptidase activity
protein kinase C binding
SH3 domain binding
zinc ion binding - Gene Ontology Cellular Component:
- cell surface
extracellular exosome
extracellular space
focal adhesion
integral component of membrane
intrinsic component of external side of plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Cone-rod dystrophy
Disulfide bond
Glycoprotein
Hydrolase
Membrane
Metal-binding
Metalloprotease
Protease
Reference proteome
Secreted
Signal
Transmembrane
Transmembrane helix
Zinc - Interacts With:
- Q9UI95; Q9UKS6; Q99962