Names & Taxonomy
- Uniprot ID:
- Q13427
- Entry Name:
- PPIG_HUMAN
- Status:
- reviewed
- Protein Names:
- Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G)
- Gene Names:
- PPIG
- Gene Names Primary:
- PPIG
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 754
- Sequence:
- MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAVKHNKEFLLSMANRGKDTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPGTDEDKSG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus matrix
Function
- Function:
- PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.
- Catalytic Activity:
- Peptidylproline (omega=180) = peptidylproline (omega=0).
- Enzyme Regulation:
- ENZYME REGULATION: Cyclosporin A (CsA)-sensitive.
- Cross Reference Drug Bank:
- DB00172
- Gene Ontology Go:
- cytoplasm
nuclear matrix
nuclear speck
nucleoplasm
nucleus
cyclosporin A binding
peptidyl-prolyl cis-trans isomerase activity
poly(A) RNA binding
protein folding
RNA splicing - Gene Ontology Biological Process:
- protein folding
RNA splicing - Gene Ontology Molecular Function:
- cyclosporin A binding
peptidyl-prolyl cis-trans isomerase activity
poly(A) RNA binding - Gene Ontology Cellular Component:
- cytoplasm
nuclear matrix
nuclear speck
nucleoplasm
nucleus - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cyclosporin
Isomerase
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Rotamase - Interacts With:
- Q8N7W2-2; Q8NHQ1; O75553; Q9UI36-2; Q96C98; Q8NC69; P17931; Q6NVH9; Q15365; Q9UL42; Q96CD2; Q14498; Q16637; Q12800; Q9NVV9