Names & Taxonomy

Uniprot ID:
Q13426
Entry Name:
XRCC4_HUMAN
Status:
reviewed
Protein Names:
DNA repair protein XRCC4 (X-ray repair cross-complementing protein 4)
Gene Names:
XRCC4
Gene Names Primary:
XRCC4
Organism:
Homo sapiens (Human)

Structure

Length:
336
Sequence:
MERKISRIHLVSEPSITHFLQVSWEKTLESGFVITLTDGHSAWTGTVSESEISQEADDMAMEKGKYVGELRKALLSGAGPADVYTFNFSKESCYFFFEKNLKDVSFRLGSFNLEKVENPAEVIRELICYCLDTIAENQAKNEHLQKENERLLRDWNDVQGRFEKCVSAKEALETDLYKRFILVLNEKKTKIRSLHNKLLNAAQEREKDIKQEGETAICSEMTADRDPVYDESTDEESENQTDLSGLASAAVSKDDSIISSLDVTDIAPSRKRRQRMQRNLGTEPKMAPQENQLQEKENSRPDSSLPETSKKEHISAENMSLETLRNSSPEDLFDEI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus

Function

Function:
Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
Gene Ontology Go:
cell junction
centrosome
cytosol
DNA ligase IV complex
DNA-dependent protein kinase-DNA ligase 4 complex
nonhomologous end joining complex
nucleoplasm
nucleus
protein C-terminus binding
cellular protein metabolic process
cellular response to lithium ion
DNA ligation involved in DNA repair
DNA recombination
DNA repair
double-strand break repair
double-strand break repair via nonhomologous end joining
establishment of integrated proviral latency
positive regulation of ligase activity
post-translational protein modification
protein sumoylation
response to X-ray
viral process
Gene Ontology Biological Process:
cellular protein metabolic process
cellular response to lithium ion
DNA ligation involved in DNA repair
DNA recombination
DNA repair
double-strand break repair
double-strand break repair via nonhomologous end joining
establishment of integrated proviral latency
positive regulation of ligase activity
post-translational protein modification
protein sumoylation
response to X-ray
viral process
Gene Ontology Molecular Function:
protein C-terminus binding
Gene Ontology Cellular Component:
cell junction
centrosome
cytosol
DNA-dependent protein kinase-DNA ligase 4 complex
DNA ligase IV complex
nonhomologous end joining complex
nucleoplasm
nucleus
Keywords:
3D-structure
Alternative splicing
Coiled coil
Complete proteome
DNA damage
DNA recombination
DNA repair
Disease mutation
Dwarfism
Isopeptide bond
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Ubl conjugation
Interacts With:
Q8IW19; Q7Z2E3; Q2TB18; O00499; Q8IZU0; P49917; Q9H9Q4; Q96T60

Publication

PubMed ID:
8548796 14702039 15489334 9259561 9430729 15177042 9242410 10854421 10757784 12509254 12547193 15380105 16412978 16439205 16478998 17396150 17353262 18077224 18669648 19690332 20068231 21269460 21406692 24389050 24275569 25728776 25839420 26255102 25941166 25670504 25574025 11702069 14607114