Names & Taxonomy
- Uniprot ID:
- Q13423
- Entry Name:
- NNTM_HUMAN
- Status:
- reviewed
- Protein Names:
- NAD(P) transhydrogenase, mitochondrial (EC 1.6.1.2) (Nicotinamide nucleotide transhydrogenase) (Pyridine nucleotide transhydrogenase)
- Gene Names:
- NNT
- Gene Names Primary:
- NNT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1086
- Sequence:
- MANLLKTVVTGCSCPLLSNLGSCKGLRVKKDFLRTFYTHQELWCKAPVKPGIPYKQLTVGVPKEIFQNEKRVALSPAGVQNLVKQGFNVVVESGAGEASKFSDDHYRVAGAQIQGAKEVLASDLVVKVRAPMVNPTLGVHEADLLKTSGTLISFIYPAQNPELLNKLSQRKTTVLAMDQVPRVTIAQGYDALSSMANIAGYKAVVLAANHFGRFFTGQITAAGKVPPAKILIVGGGVAGLASAGAAKSMGAIVRGFDTRAAALEQFKSLGAEPLEVDLKESGEGQGGYAKEMSKEFIEAEMKLFAQQCKEVDILISTALIPGKKAPVLFNKEMIESMKEGSVVVDLAAEAGGNFETTKPGELYIHKGITHIGYTDLPSRMATQASTLYSNNITKLLKAISPDKDNFYFDVKDDFDFGTMGHVIRGTVVMKDGKVIFPAPTPKNIPQGAPVKQKTVAELEAEKAATITPFRKTMSTASAYTAGLTGILGLGIAAPNLAFSQMVTTFGLAGIVGYHTVWGVTPALHSPLMSVTNAISGLTAVGGLALMGGHLYPSTTSQGLAALAAFISSVNIAGGFLVTQRMLDMFKRPTDPPEYNYLYLLPAGTFVGGYLAALYSGYNIEQIMYLGSGLCCVGALAGLSTQGTARLGNALGMIGVAGGLAATLGVLKPGPELLAQMSGAMALGGTIGLTIAKRIQISDLPQLVAAFHSLVGLAAVLTCIAEYIIEYPHFATDAAANLTKIVAYLGTYIGGVTFSGSLIAYGKLQGLLKSAPLLLPGRHLLNAGLLAASVGGIIPFMVDPSFTTGITCLGSVSALSAVMGVTLTAAIGGADMPVVITVLNSYSGWALCAEGFLLNNNLLTIVGALIGSSGAILSYIMCVAMNRSLANVILGGYGTTSTAGGKPMEISGTHTEINLDNAIDMIREANSIIITPGYGLCAAKAQYPIADLVKMLTEQGKKVRFGIHPVAGRMPGQLNVLLAEAGVPYDIVLEMDEINHDFPDTDLVLVIGANDTVNSAAQEDPNSIIAGMPVLEVWKSKQVIVMKRSLGVGYAAVDNPIFYKPNTAMLLGDAKKTCDALQAKVRESYQK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane
Function
- Function:
- The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.
- Catalytic Activity:
- NADPH + NAD(+) = NADP(+) + NADH.
- Gene Ontology Go:
- integral component of membrane
membrane
mitochondrial inner membrane
mitochondrial respiratory chain
mitochondrion
NAD binding
NAD(P)+ transhydrogenase (AB-specific) activity
NAD(P)+ transhydrogenase (B-specific) activity
NAD(P)+ transhydrogenase activity
NADP binding
cell redox homeostasis
cellular metabolic process
hydrogen ion transmembrane transport
NADPH regeneration
oxidation-reduction process
proton transport
reactive oxygen species metabolic process
small molecule metabolic process
tricarboxylic acid cycle - Gene Ontology Biological Process:
- cell redox homeostasis
cellular metabolic process
hydrogen ion transmembrane transport
NADPH regeneration
oxidation-reduction process
proton transport
reactive oxygen species metabolic process
small molecule metabolic process
tricarboxylic acid cycle - Gene Ontology Molecular Function:
- NAD(P)+ transhydrogenase (AB-specific) activity
NAD(P)+ transhydrogenase (B-specific) activity
NAD(P)+ transhydrogenase activity
NAD binding
NADP binding - Gene Ontology Cellular Component:
- integral component of membrane
membrane
mitochondrial inner membrane
mitochondrial respiratory chain
mitochondrion - Keywords:
- 3D-structure
Acetylation
Complete proteome
Disease mutation
Membrane
Mitochondrion
Mitochondrion inner membrane
NAD
NADP
Oxidoreductase
Reference proteome
Transit peptide
Transmembrane
Transmembrane helix