Names & Taxonomy

Uniprot ID:
Q13393
Entry Name:
PLD1_HUMAN
Status:
reviewed
Protein Names:
Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1)
Gene Names:
PLD1
Gene Names Primary:
PLD1
Organism:
Homo sapiens (Human)

Structure

Length:
1074
Sequence:
MSLKNEPRVNTSALQKIAADMSNIIENLDTRELHFEGEEVDYDVSPSDPKIQEVYIPFSAIYNTQGFKEPNIQTYLSGCPIKAQVLEVERFTSTTRVPSINLYTIELTHGEFKWQVKRKFKHFQEFHRELLKYKAFIRIPIPTRRHTFRRQNVREEPREMPSLPRSSENMIREEQFLGRRKQLEDYLTKILKMPMYRNYHATTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQGRACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLKDKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGLKPHFKLFHPSSESEQGLTRPHADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLLPKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFFISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCFRVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFINKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSEESLLPSVGTKEAIVPMEVWT
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, perinuclear region

Function

Function:
Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).
Catalytic Activity:
A phosphatidylcholine + H(2)O = choline + a phosphatidate.
Enzyme Regulation:
ENZYME REGULATION: Stimulated by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, activated by the phosphokinase C-alpha, by the ADP-ribosylation factor-1 (ARF-1), and to a lesser extent by GTP-binding proteins: RHO A, RAC-1 and CDC42. Inhibited by oleate.
Cross Reference Drug Bank:
DB00122 DB09031
Gene Ontology Go:
apical plasma membrane
endocytic vesicle
endoplasmic reticulum membrane
endosome
Golgi apparatus
Golgi membrane
late endosome membrane
lysosomal membrane
membrane
perinuclear region of cytoplasm
N-acylphosphatidylethanolamine-specific phospholipase D activity
phosphatidylinositol binding
phospholipase D activity
cell motility
chemotaxis
glycerophospholipid biosynthetic process
inositol lipid-mediated signaling
lipid catabolic process
phosphatidic acid biosynthetic process
phosphatidylglycerol biosynthetic process
phospholipid metabolic process
Ras protein signal transduction
regulation of cell migration
regulation of microvillus assembly
regulation of phagocytosis
small GTPase mediated signal transduction
small molecule metabolic process
Gene Ontology Biological Process:
cell motility
chemotaxis
glycerophospholipid biosynthetic process
inositol lipid-mediated signaling
lipid catabolic process
phosphatidic acid biosynthetic process
phosphatidylglycerol biosynthetic process
phospholipid metabolic process
Ras protein signal transduction
regulation of cell migration
regulation of microvillus assembly
regulation of phagocytosis
small GTPase mediated signal transduction
small molecule metabolic process
Gene Ontology Molecular Function:
N-acylphosphatidylethanolamine-specific phospholipase D activity
phosphatidylinositol binding
phospholipase D activity
Gene Ontology Cellular Component:
apical plasma membrane
endocytic vesicle
endoplasmic reticulum membrane
endosome
Golgi apparatus
Golgi membrane
late endosome membrane
lysosomal membrane
membrane
perinuclear region of cytoplasm
Keywords:
Alternative splicing
Complete proteome
Cytoplasm
Endoplasmic reticulum
Endosome
Golgi apparatus
Hydrolase
Lipid degradation
Lipid metabolism
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Interacts With:
P23528

Publication

PubMed ID:
8530346 9013646 9761774 15489334 9582313 11032811 17081983 18669648 24275569 25944712