Names & Taxonomy
- Uniprot ID:
- Q13393
- Entry Name:
- PLD1_HUMAN
- Status:
- reviewed
- Protein Names:
- Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1)
- Gene Names:
- PLD1
- Gene Names Primary:
- PLD1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1074
- Sequence:
- MSLKNEPRVNTSALQKIAADMSNIIENLDTRELHFEGEEVDYDVSPSDPKIQEVYIPFSAIYNTQGFKEPNIQTYLSGCPIKAQVLEVERFTSTTRVPSINLYTIELTHGEFKWQVKRKFKHFQEFHRELLKYKAFIRIPIPTRRHTFRRQNVREEPREMPSLPRSSENMIREEQFLGRRKQLEDYLTKILKMPMYRNYHATTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQGRACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLKDKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGLKPHFKLFHPSSESEQGLTRPHADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLLPKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFFISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCFRVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFINKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSEESLLPSVGTKEAIVPMEVWT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, perinuclear region
Function
- Function:
- Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).
- Catalytic Activity:
- A phosphatidylcholine + H(2)O = choline + a phosphatidate.
- Enzyme Regulation:
- ENZYME REGULATION: Stimulated by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, activated by the phosphokinase C-alpha, by the ADP-ribosylation factor-1 (ARF-1), and to a lesser extent by GTP-binding proteins: RHO A, RAC-1 and CDC42. Inhibited by oleate.
- Cross Reference Drug Bank:
- DB00122 DB09031
- Gene Ontology Go:
- apical plasma membrane
endocytic vesicle
endoplasmic reticulum membrane
endosome
Golgi apparatus
Golgi membrane
late endosome membrane
lysosomal membrane
membrane
perinuclear region of cytoplasm
N-acylphosphatidylethanolamine-specific phospholipase D activity
phosphatidylinositol binding
phospholipase D activity
cell motility
chemotaxis
glycerophospholipid biosynthetic process
inositol lipid-mediated signaling
lipid catabolic process
phosphatidic acid biosynthetic process
phosphatidylglycerol biosynthetic process
phospholipid metabolic process
Ras protein signal transduction
regulation of cell migration
regulation of microvillus assembly
regulation of phagocytosis
small GTPase mediated signal transduction
small molecule metabolic process - Gene Ontology Biological Process:
- cell motility
chemotaxis
glycerophospholipid biosynthetic process
inositol lipid-mediated signaling
lipid catabolic process
phosphatidic acid biosynthetic process
phosphatidylglycerol biosynthetic process
phospholipid metabolic process
Ras protein signal transduction
regulation of cell migration
regulation of microvillus assembly
regulation of phagocytosis
small GTPase mediated signal transduction
small molecule metabolic process - Gene Ontology Molecular Function:
- N-acylphosphatidylethanolamine-specific phospholipase D activity
phosphatidylinositol binding
phospholipase D activity - Gene Ontology Cellular Component:
- apical plasma membrane
endocytic vesicle
endoplasmic reticulum membrane
endosome
Golgi apparatus
Golgi membrane
late endosome membrane
lysosomal membrane
membrane
perinuclear region of cytoplasm - Keywords:
- Alternative splicing
Complete proteome
Cytoplasm
Endoplasmic reticulum
Endosome
Golgi apparatus
Hydrolase
Lipid degradation
Lipid metabolism
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Reference proteome
Repeat - Interacts With:
- P23528