Names & Taxonomy

Uniprot ID:
Q13336
Entry Name:
UT1_HUMAN
Status:
reviewed
Protein Names:
Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter, erythrocyte)
Gene Names:
SLC14A1 HUT11 JK RACH1 UT1 UTE
Gene Names Primary:
SLC14A1
Organism:
Homo sapiens (Human)

Structure

Length:
389
Sequence:
MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKELANQLKDKPVVLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDLSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIYKMPLSKVTYPEENRIFYLQAKKRMVESPL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane
Intramembrane:
INTRAMEM 52 69 Helical.

Function

Function:
Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.
Cross Reference Drug Bank:
DB03904
Gene Ontology Go:
basolateral plasma membrane
integral component of plasma membrane
intracellular membrane-bounded organelle
nucleolus
plasma membrane
urea channel activity
water transmembrane transporter activity
transmembrane transport
urea transmembrane transport
urea transport
Gene Ontology Biological Process:
transmembrane transport
urea transmembrane transport
urea transport
Gene Ontology Molecular Function:
urea channel activity
water transmembrane transporter activity
Gene Ontology Cellular Component:
basolateral plasma membrane
integral component of plasma membrane
intracellular membrane-bounded organelle
nucleolus
plasma membrane
Keywords:
Alternative splicing
Blood group antigen
Cell membrane
Complete proteome
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
7989337 8573795 9215669 10514515 14702039 15489334 18028269 23219802 10942407 10644814 18980618