Names & Taxonomy
- Uniprot ID:
- Q13224
- Entry Name:
- NMDE2_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3)
- Gene Names:
- GRIN2B NMDAR2B
- Gene Names Primary:
- GRIN2B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1484
- Sequence:
- MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILRLLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFSDYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISKKPLDIGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKRRKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTKENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVVSGVPAPWEKNLTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRCEACKKAGNLYDISEDNSLQELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPRSVSLKDKGRFMDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPDRVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPARFQKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Function
- Function:
- NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
- Cross Reference Drug Bank:
- DB00659 DB06151 DB00289 DB00949 DB00996 DB00502 DB08954 DB06738 DB01043 DB04896 DB00312 DB00454 DB01174 DB00418
- Gene Ontology Go:
- cell junction
cell surface
integral component of plasma membrane
intracellular
neuron projection
NMDA selective glutamate receptor complex
plasma membrane
postsynaptic membrane
extracellular-glutamate-gated ion channel activity
glycine binding
NMDA glutamate receptor activity
zinc ion binding
activation of MAPKK activity
axon guidance
ephrin receptor signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
glutamate receptor signaling pathway
innate immune response
insulin receptor signaling pathway
ionotropic glutamate receptor signaling pathway
learning or memory
MAPK cascade
neurotrophin TRK receptor signaling pathway
Ras protein signal transduction
response to ethanol
small GTPase mediated signal transduction
synaptic transmission
transport
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- activation of MAPKK activity
axon guidance
ephrin receptor signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
glutamate receptor signaling pathway
innate immune response
insulin receptor signaling pathway
ionotropic glutamate receptor signaling pathway
learning or memory
MAPK cascade
neurotrophin TRK receptor signaling pathway
Ras protein signal transduction
response to ethanol
small GTPase mediated signal transduction
synaptic transmission
transport
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- extracellular-glutamate-gated ion channel activity
glycine binding
NMDA glutamate receptor activity
zinc ion binding - Gene Ontology Cellular Component:
- cell junction
cell surface
integral component of plasma membrane
intracellular
neuron projection
NMDA selective glutamate receptor complex
plasma membrane
postsynaptic membrane - Keywords:
- 3D-structure
Calcium
Cell junction
Cell membrane
Chromosomal rearrangement
Complete proteome
Disease mutation
Disulfide bond
Epilepsy
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Magnesium
Membrane
Mental retardation
Metal-binding
Phosphoprotein
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport
Zinc - Interacts With:
- Q9UQM7; Q62936; P78352; P31016; P62139