Names & Taxonomy
- Uniprot ID:
- Q13133
- Entry Name:
- NR1H3_HUMAN
- Status:
- reviewed
- Protein Names:
- Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3)
- Gene Names:
- NR1H3 LXRA
- Gene Names Primary:
- NR1H3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 447
- Sequence:
- MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920).
- Gene Ontology Go:
- nuclear chromatin
nucleoplasm
nucleus
receptor complex
RNA polymerase II transcription factor complex
cholesterol binding
DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
sequence-specific DNA binding
steroid hormone receptor activity
sterol response element binding
transcription coactivator activity
transcription regulatory region DNA binding
zinc ion binding
apoptotic cell clearance
cellular response to lipopolysaccharide
cholesterol homeostasis
gene expression
intracellular receptor signaling pathway
lipid homeostasis
negative regulation of cholesterol storage
negative regulation of inflammatory response
negative regulation of interferon-gamma-mediated signaling pathway
negative regulation of lipid transport
negative regulation of macrophage activation
negative regulation of macrophage derived foam cell differentiation
negative regulation of pancreatic juice secretion
negative regulation of pinocytosis
negative regulation of secretion of lysosomal enzymes
negative regulation of transcription from RNA polymerase II promoter
positive regulation of cellular protein metabolic process
positive regulation of cholesterol efflux
positive regulation of cholesterol homeostasis
positive regulation of cholesterol transport
positive regulation of fatty acid biosynthetic process
positive regulation of lipoprotein lipase activity
positive regulation of receptor biosynthetic process
positive regulation of toll-like receptor 4 signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
positive regulation of triglyceride biosynthetic process
regulation of cholesterol homeostasis
regulation of circadian rhythm
response to progesterone
sterol homeostasis
transcription initiation from RNA polymerase II promoter
triglyceride homeostasis - Gene Ontology Biological Process:
- apoptotic cell clearance
cellular response to lipopolysaccharide
cholesterol homeostasis
gene expression
intracellular receptor signaling pathway
lipid homeostasis
negative regulation of cholesterol storage
negative regulation of inflammatory response
negative regulation of interferon-gamma-mediated signaling pathway
negative regulation of lipid transport
negative regulation of macrophage activation
negative regulation of macrophage derived foam cell differentiation
negative regulation of pancreatic juice secretion
negative regulation of pinocytosis
negative regulation of secretion of lysosomal enzymes
negative regulation of transcription from RNA polymerase II promoter
positive regulation of cellular protein metabolic process
positive regulation of cholesterol efflux
positive regulation of cholesterol homeostasis
positive regulation of cholesterol transport
positive regulation of fatty acid biosynthetic process
positive regulation of lipoprotein lipase activity
positive regulation of receptor biosynthetic process
positive regulation of toll-like receptor 4 signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of triglyceride biosynthetic process
regulation of cholesterol homeostasis
regulation of circadian rhythm
response to progesterone
sterol homeostasis
transcription initiation from RNA polymerase II promoter
triglyceride homeostasis - Gene Ontology Molecular Function:
- cholesterol binding
DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
sequence-specific DNA binding
steroid hormone receptor activity
sterol response element binding
transcription coactivator activity
transcription regulatory region DNA binding
zinc ion binding - Gene Ontology Cellular Component:
- nuclear chromatin
nucleoplasm
nucleus
receptor complex
RNA polymerase II transcription factor complex - Keywords:
- 3D-structure
Activator
Alternative splicing
Complete proteome
DNA-binding
Metal-binding
Nucleus
Polymorphism
Receptor
Reference proteome
Transcription
Transcription regulation
Zinc
Zinc-finger - Interacts With:
- O60869; O60341; Q99750; Q15788; O75376; Q5STP9; P48443; O43463