Names & Taxonomy
- Uniprot ID:
- Q13003
- Entry Name:
- GRIK3_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutamate receptor ionotropic, kainate 3 (GluK3) (Excitatory amino acid receptor 5) (EAA5) (Glutamate receptor 7) (GluR-7) (GluR7)
- Gene Names:
- GRIK3 GLUR7
- Gene Names Primary:
- GRIK3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 919
- Sequence:
- MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMACSTSLAPVFP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.
- Gene Ontology Go:
- axon
cell junction
dendrite
dendrite cytoplasm
integral component of plasma membrane
perikaryon
plasma membrane
postsynaptic membrane
terminal bouton
adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
extracellular-glutamate-gated ion channel activity
glutamate receptor activity
ionotropic glutamate receptor activity
kainate selective glutamate receptor activity
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
glutamate receptor signaling pathway
ionotropic glutamate receptor signaling pathway
negative regulation of synaptic transmission, glutamatergic
regulation of membrane potential
synaptic transmission - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
glutamate receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
ionotropic glutamate receptor signaling pathway
negative regulation of synaptic transmission, glutamatergic
regulation of membrane potential
synaptic transmission - Gene Ontology Molecular Function:
- adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
extracellular-glutamate-gated ion channel activity
glutamate receptor activity
ionotropic glutamate receptor activity
kainate selective glutamate receptor activity - Gene Ontology Cellular Component:
- axon
cell junction
dendrite
dendrite cytoplasm
integral component of plasma membrane
perikaryon
plasma membrane
postsynaptic membrane
terminal bouton - Keywords:
- Alternative splicing
Cell junction
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Phosphoprotein
Polymorphism
Postsynaptic cell membrane
RNA editing
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport