Names & Taxonomy

Uniprot ID:
Q12913
Entry Name:
PTPRJ_HUMAN
Status:
reviewed
Protein Names:
Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148)
Gene Names:
PTPRJ DEP1
Gene Names Primary:
PTPRJ
Organism:
Homo sapiens (Human)

Structure

Length:
1337
Sequence:
MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRYSDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIYENLAPVTTFGKTNGYIA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane

Function

Function:
Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.
Catalytic Activity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Active Site:
ACT_SITE 1239 1239 Phosphocysteine intermediate.
Gene Ontology Go:
cell surface
cell-cell junction
extracellular exosome
immunological synapse
integral component of plasma membrane
plasma membrane
ruffle membrane
beta-catenin binding
delta-catenin binding
gamma-catenin binding
mitogen-activated protein kinase binding
phosphatase activity
platelet-derived growth factor receptor binding
protein kinase binding
protein tyrosine phosphatase activity
contact inhibition
negative regulation of cell growth
negative regulation of cell migration
negative regulation of cell proliferation
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of MAP kinase activity
negative regulation of platelet-derived growth factor receptor signaling pathway
negative regulation of protein kinase B signaling
negative regulation of T cell receptor signaling pathway
negative regulation of vascular permeability
peptidyl-tyrosine dephosphorylation
platelet-derived growth factor receptor signaling pathway
positive chemotaxis
positive regulation of cell adhesion
positive regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
regulation of cell adhesion
T cell receptor signaling pathway
Gene Ontology Biological Process:
contact inhibition
negative regulation of cell growth
negative regulation of cell migration
negative regulation of cell proliferation
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of MAP kinase activity
negative regulation of platelet-derived growth factor receptor signaling pathway
negative regulation of protein kinase B signaling
negative regulation of T cell receptor signaling pathway
negative regulation of vascular permeability
peptidyl-tyrosine dephosphorylation
platelet-derived growth factor receptor signaling pathway
positive chemotaxis
positive regulation of cell adhesion
positive regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
regulation of cell adhesion
T cell receptor signaling pathway
Gene Ontology Molecular Function:
beta-catenin binding
delta-catenin binding
gamma-catenin binding
mitogen-activated protein kinase binding
phosphatase activity
platelet-derived growth factor receptor binding
protein kinase binding
protein tyrosine phosphatase activity
Gene Ontology Cellular Component:
cell-cell junction
cell surface
extracellular exosome
immunological synapse
integral component of plasma membrane
plasma membrane
ruffle membrane
Keywords:
3D-structure
Alternative splicing
Cell junction
Cell membrane
Cell projection
Complete proteome
Direct protein sequencing
Glycoprotein
Hydrolase
Membrane
Polymorphism
Protein phosphatase
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Interacts With:
P35222; O60716; P04626; P17948; P36888; Q13480; P10912; P35968; P28482; P27361; P08581; P09619; Q02763

Publication

PubMed ID:
7937872 7994032 16554811 15489334 12089527 8483328 9531590 9780142 10821867 11259588 12062403 12370829 12475979 12913111 14709717 16335952 16778204 16682945 18348712 19246339 19836242 19332538 19494114 19159218 18936167 21091576 19922411 21262971 15378013