Names & Taxonomy

Uniprot ID:
Q12864
Entry Name:
CAD17_HUMAN
Status:
reviewed
Protein Names:
Cadherin-17 (Intestinal peptide-associated transporter HPT-1) (Liver-intestine cadherin) (LI-cadherin)
Gene Names:
CDH17
Gene Names Primary:
CDH17
Organism:
Homo sapiens (Human)

Structure

Length:
832
Sequence:
MILQAHLHSLCLLMLYLATGYGQEGKFSGPLKPMTFSIYEGQEPSQIIFQFKANPPAVTFELTGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPKPVEMVENSTDPHPIKITQVRWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPLVFGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIVSLPVTFCSCVEGSCFRPAGHQTGIPTVGMAVGILLTTLLVIGIILAVVFIRIKKDKGKDNVESAQASEVKPLRS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.
Gene Ontology Go:
basolateral plasma membrane
cell surface
integral component of membrane
plasma membrane
calcium ion binding
integrin binding
proton-dependent oligopeptide secondary active transmembrane transporter activity
transporter activity
adherens junction organization
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell adhesion
cell junction assembly
cell-cell junction organization
germinal center B cell differentiation
homophilic cell adhesion via plasma membrane adhesion molecules
integrin-mediated signaling pathway
marginal zone B cell differentiation
oligopeptide transmembrane transport
oligopeptide transport
positive regulation of integrin activation by cell surface receptor linked signal transduction
spleen development
transport
Gene Ontology Biological Process:
adherens junction organization
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell adhesion
cell-cell junction organization
cell junction assembly
germinal center B cell differentiation
homophilic cell adhesion via plasma membrane adhesion molecules
integrin-mediated signaling pathway
marginal zone B cell differentiation
oligopeptide transmembrane transport
oligopeptide transport
positive regulation of integrin activation by cell surface receptor linked signal transduction
spleen development
transport
Gene Ontology Molecular Function:
calcium ion binding
integrin binding
proton-dependent oligopeptide secondary active transmembrane transporter activity
transporter activity
Gene Ontology Cellular Component:
basolateral plasma membrane
cell surface
integral component of membrane
plasma membrane
Keywords:
Calcium
Cell adhesion
Cell membrane
Complete proteome
Glycoprotein
Membrane
Metal-binding
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
8153632 16421571 15489334