Names & Taxonomy
- Uniprot ID:
- Q12864
- Entry Name:
- CAD17_HUMAN
- Status:
- reviewed
- Protein Names:
- Cadherin-17 (Intestinal peptide-associated transporter HPT-1) (Liver-intestine cadherin) (LI-cadherin)
- Gene Names:
- CDH17
- Gene Names Primary:
- CDH17
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 832
- Sequence:
- MILQAHLHSLCLLMLYLATGYGQEGKFSGPLKPMTFSIYEGQEPSQIIFQFKANPPAVTFELTGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPKPVEMVENSTDPHPIKITQVRWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPLVFGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIVSLPVTFCSCVEGSCFRPAGHQTGIPTVGMAVGILLTTLLVIGIILAVVFIRIKKDKGKDNVESAQASEVKPLRS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.
- Gene Ontology Go:
- basolateral plasma membrane
cell surface
integral component of membrane
plasma membrane
calcium ion binding
integrin binding
proton-dependent oligopeptide secondary active transmembrane transporter activity
transporter activity
adherens junction organization
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell adhesion
cell junction assembly
cell-cell junction organization
germinal center B cell differentiation
homophilic cell adhesion via plasma membrane adhesion molecules
integrin-mediated signaling pathway
marginal zone B cell differentiation
oligopeptide transmembrane transport
oligopeptide transport
positive regulation of integrin activation by cell surface receptor linked signal transduction
spleen development
transport - Gene Ontology Biological Process:
- adherens junction organization
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell adhesion
cell-cell junction organization
cell junction assembly
germinal center B cell differentiation
homophilic cell adhesion via plasma membrane adhesion molecules
integrin-mediated signaling pathway
marginal zone B cell differentiation
oligopeptide transmembrane transport
oligopeptide transport
positive regulation of integrin activation by cell surface receptor linked signal transduction
spleen development
transport - Gene Ontology Molecular Function:
- calcium ion binding
integrin binding
proton-dependent oligopeptide secondary active transmembrane transporter activity
transporter activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
cell surface
integral component of membrane
plasma membrane - Keywords:
- Calcium
Cell adhesion
Cell membrane
Complete proteome
Glycoprotein
Membrane
Metal-binding
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Transport