Names & Taxonomy
- Uniprot ID:
- Q08881
- Entry Name:
- ITK_HUMAN
- Status:
- reviewed
- Protein Names:
- Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk)
- Gene Names:
- ITK EMT LYK
- Gene Names Primary:
- ITK
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 620
- Sequence:
- MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESGL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 482 482 Proton acceptor.
- Cross Reference Drug Bank:
- DB06589
- Gene Ontology Go:
- cell-cell junction
cytosol
extrinsic component of cytoplasmic side of plasma membrane
ATP binding
metal ion binding
non-membrane spanning protein tyrosine kinase activity
activation of phospholipase C activity
adaptive immune response
cellular defense response
cytokine production
Fc-epsilon receptor signaling pathway
innate immune response
interferon-gamma production
interleukin-4 production
intracellular signal transduction
NK T cell differentiation
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
signal transduction
T cell activation
T cell receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway - Gene Ontology Biological Process:
- activation of phospholipase C activity
adaptive immune response
cellular defense response
cytokine production
Fc-epsilon receptor signaling pathway
innate immune response
interferon-gamma production
interleukin-4 production
intracellular signal transduction
NK T cell differentiation
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
signal transduction
T cell activation
T cell receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway - Gene Ontology Molecular Function:
- ATP binding
metal ion binding
non-membrane spanning protein tyrosine kinase activity - Gene Ontology Cellular Component:
- cell-cell junction
cytosol
extrinsic component of cytoplasmic side of plasma membrane - Keywords:
- 3D-structure
ATP-binding
Adaptive immunity
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Immunity
Kinase
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
SH2 domain
SH3 domain
Transferase
Tyrosine-protein kinase
Ubl conjugation
Zinc
Zinc-finger - Interacts With:
- P04626; P48023