Names & Taxonomy
- Uniprot ID:
- Q08289
- Entry Name:
- CACB2_HUMAN
- Status:
- reviewed
- Protein Names:
- Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB)
- Gene Names:
- CACNB2 CACNLB2 MYSB
- Gene Names Primary:
- CACNB2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 660
- Sequence:
- MVQRDMSKSPPTAAAAVAQEIQMELLENVAPAGALGAAAQSYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane, sarcolemma
Function
- Function:
- The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
- Cross Reference Drug Bank:
- DB00381 DB04855 DB01023 DB00270 DB00653 DB00622 DB01115 DB06712 DB00393 DB00401 DB01054 DB00421 DB00661
- Gene Ontology Go:
- integral component of plasma membrane
L-type voltage-gated calcium channel complex
plasma membrane
voltage-gated calcium channel complex
calcium channel activity
calcium channel regulator activity
voltage-gated calcium channel activity
axon guidance
calcium ion import
cardiac conduction
neuromuscular junction development
positive regulation of calcium ion transport
regulation of voltage-gated calcium channel activity
synaptic transmission
transport
visual perception - Gene Ontology Biological Process:
- axon guidance
calcium ion import
cardiac conduction
neuromuscular junction development
positive regulation of calcium ion transport
regulation of voltage-gated calcium channel activity
synaptic transmission
transport
visual perception - Gene Ontology Molecular Function:
- calcium channel activity
calcium channel regulator activity
voltage-gated calcium channel activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
L-type voltage-gated calcium channel complex
plasma membrane
voltage-gated calcium channel complex - Keywords:
- Alternative splicing
Brugada syndrome
Calcium
Calcium channel
Calcium transport
Cell membrane
Complete proteome
Disease mutation
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
SH3 domain
Transport
Voltage-gated channel