Names & Taxonomy

Uniprot ID:
Q08289
Entry Name:
CACB2_HUMAN
Status:
reviewed
Protein Names:
Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB)
Gene Names:
CACNB2 CACNLB2 MYSB
Gene Names Primary:
CACNB2
Organism:
Homo sapiens (Human)

Structure

Length:
660
Sequence:
MVQRDMSKSPPTAAAAVAQEIQMELLENVAPAGALGAAAQSYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane, sarcolemma

Function

Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Cross Reference Drug Bank:
DB00381 DB04855 DB01023 DB00270 DB00653 DB00622 DB01115 DB06712 DB00393 DB00401 DB01054 DB00421 DB00661
Gene Ontology Go:
integral component of plasma membrane
L-type voltage-gated calcium channel complex
plasma membrane
voltage-gated calcium channel complex
calcium channel activity
calcium channel regulator activity
voltage-gated calcium channel activity
axon guidance
calcium ion import
cardiac conduction
neuromuscular junction development
positive regulation of calcium ion transport
regulation of voltage-gated calcium channel activity
synaptic transmission
transport
visual perception
Gene Ontology Biological Process:
axon guidance
calcium ion import
cardiac conduction
neuromuscular junction development
positive regulation of calcium ion transport
regulation of voltage-gated calcium channel activity
synaptic transmission
transport
visual perception
Gene Ontology Molecular Function:
calcium channel activity
calcium channel regulator activity
voltage-gated calcium channel activity
Gene Ontology Cellular Component:
integral component of plasma membrane
L-type voltage-gated calcium channel complex
plasma membrane
voltage-gated calcium channel complex
Keywords:
Alternative splicing
Brugada syndrome
Calcium
Calcium channel
Calcium transport
Cell membrane
Complete proteome
Disease mutation
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
SH3 domain
Transport
Voltage-gated channel

Publication

PubMed ID:
8494331 9254841 12042350 14762176 15164054 15489334 17525370 22419821 16959974 17224476