Names & Taxonomy
- Uniprot ID:
- Q08211
- Entry Name:
- DHX9_HUMAN
- Status:
- reviewed
- Protein Names:
- ATP-dependent RNA helicase A (RHA) (EC 3.6.4.13) (DEAH box protein 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II)
- Gene Names:
- DHX9 DDX9 LKP NDH2
- Gene Names Primary:
- DHX9
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1270
- Sequence:
- MGDVKNFLYAWCGKRKMTPSYEIRAVGNKNRQKFMCEVQVEGYNYTGMGNSTNKKDAQSNAARDFVNYLVRINEIKSEEVPAFGVASPPPLTDTPDTTANAEGDLPTTMGGPLPPHLALKAENNSEVGASGYGVPGPTWDRGANLKDYYSRKEEQEVQATLESEEVDLNAGLHGNWTLENAKARLNQYFQKEKIQGEYKYTQVGPDHNRSFIAEMTIYIKQLGRRIFAREHGSNKKLAAQSCALSLVRQLYHLGVVEAYSGLTKKKEGETVEPYKVNLSQDLEHQLQNIIQELNLEILPPPEDPSVPVALNIGKLAQFEPSQRQNQVGVVPWSPPQSNWNPWTSSNIDEGPLAFATPEQISMDLKNELMYQLEQDHDLQAILQERELLPVKKFESEILEAISQNSVVIIRGATGCGKTTQVPQFILDDFIQNDRAAECNIVVTQPRRISAVSVAERVAFERGEEPGKSCGYSVRFESILPRPHASIMFCTVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPEVRIVLMSATIDTSMFCEYFFNCPIIEVYGRTYPVQEYFLEDCIQMTHFVPPPKDKKKKDKDDDGGEDDDANCNLICGDEYGPETRLSMSQLNEKETPFELIEALLKYIETLNVPGAVLVFLPGWNLIYTMQKHLEMNPHFGSHRYQILPLHSQIPREEQRKVFDPVPVGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFERLETHMTPEMFRTPLHEIALSIKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAICTIAAATCFPEPFINEGKRLGYIHRNFAGNRFSDHVALLSVFQAWDDARMGGEEAEIRFCEHKRLNMATLRMTWEAKVQLKEILINSGFPEDCLLTQVFTNTGPDNNLDVVISLLAFGVYPNVCYHKEKRKILTTEGRNALIHKSSVNCPFSSQDMKYPSPFFVFGEKIRTRAISAKGMTLVTPLQLLLFASKKVQSDGQIVLVDDWIKLQISHEAAACITGLRAAMEALVVEVTKQPAIISQLDPVNERMLNMIRQISRPSAAGINLMIGSTRYGDGPRPPKMARYDNGSGYRRGGSSYSGGGYGGGYSSGGYGSGGYGGSANSFRAGYGAGVGGGYRGVSRGGFRGNSGGDYRGPSGGYRGSGGFQRGGGRGAYGTGYFGQGRGGGGY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Can shuttle between nucleus and cytoplasm.
Function
- Function:
- Unwinds double-stranded DNA and RNA in a 3' to 5' direction. Alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator. Component of the CRD-mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. Positively regulates HIV-1 LTR-directed gene expression.
- Catalytic Activity:
- ATP + H(2)O = ADP + phosphate.
- Gene Ontology Go:
- centrosome
CRD-mediated mRNA stability complex
cytoplasm
cytoplasmic ribonucleoprotein granule
cytosol
intracellular ribonucleoprotein complex
membrane
nuclear stress granule
nucleolus
nucleoplasm
nucleus
ATP binding
ATP-dependent DNA helicase activity
ATP-dependent RNA helicase activity
DNA binding
poly(A) RNA binding
RNA helicase activity
RNA polymerase II transcription factor binding
CRD-mediated mRNA stabilization
DNA duplex unwinding
gene expression
innate immune response
mRNA splicing, via spliceosome
osteoblast differentiation
positive regulation of type I interferon production
protein localization to cytoplasmic stress granule
rhythmic process
RNA processing
RNA splicing - Gene Ontology Biological Process:
- CRD-mediated mRNA stabilization
DNA duplex unwinding
gene expression
innate immune response
mRNA splicing, via spliceosome
osteoblast differentiation
positive regulation of type I interferon production
protein localization to cytoplasmic stress granule
rhythmic process
RNA processing
RNA splicing - Gene Ontology Molecular Function:
- ATP binding
ATP-dependent DNA helicase activity
ATP-dependent RNA helicase activity
DNA binding
poly(A) RNA binding
RNA helicase activity
RNA polymerase II transcription factor binding - Gene Ontology Cellular Component:
- centrosome
CRD-mediated mRNA stability complex
cytoplasm
cytoplasmic ribonucleoprotein granule
cytosol
intracellular ribonucleoprotein complex
membrane
nuclear stress granule
nucleolus
nucleoplasm
nucleus - Keywords:
- 3D-structure
ATP-binding
Acetylation
Activator
Alternative splicing
Biological rhythms
Complete proteome
Cytoplasm
DNA-binding
Direct protein sequencing
Helicase
Hydrolase
Methylation
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
RNA-binding
Reference proteome
Repeat - Interacts With:
- P19525; Q9UBU9; Q99873; Q04206; P67809; Q9HA38