Names & Taxonomy
- Uniprot ID:
- Q08043
- Entry Name:
- ACTN3_HUMAN
- Status:
- reviewed
- Protein Names:
- Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein)
- Gene Names:
- ACTN3
- Gene Names Primary:
- ACTN3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 901
- Sequence:
- MMMVMQPEGLGAGEGRFAGGGGGGEYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDRLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSCDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKQNGMMEPDDFRACLISMGYDLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVASFKILAGDKNYITPEELRRELPAKQAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESDL
- Proteomes:
- UP000005640
Function
- Function:
- F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
- Gene Ontology Go:
- actin filament
cytosol
extracellular exosome
focal adhesion
intracellular
pseudopodium
calcium ion binding
integrin binding
ion channel binding
protein homodimerization activity
structural constituent of muscle
focal adhesion assembly
muscle filament sliding
negative regulation of calcineurin-NFAT signaling cascade
negative regulation of glycolytic process
negative regulation of oxidative phosphorylation
positive regulation of glucose catabolic process to lactate via pyruvate
positive regulation of skeletal muscle tissue growth
regulation of aerobic respiration
regulation of apoptotic process
regulation of the force of skeletal muscle contraction
response to denervation involved in regulation of muscle adaptation
skeletal muscle atrophy
transition between fast and slow fiber - Gene Ontology Biological Process:
- focal adhesion assembly
muscle filament sliding
negative regulation of calcineurin-NFAT signaling cascade
negative regulation of glycolytic process
negative regulation of oxidative phosphorylation
positive regulation of glucose catabolic process to lactate via pyruvate
positive regulation of skeletal muscle tissue growth
regulation of aerobic respiration
regulation of apoptotic process
regulation of the force of skeletal muscle contraction
response to denervation involved in regulation of muscle adaptation
skeletal muscle atrophy
transition between fast and slow fiber - Gene Ontology Molecular Function:
- calcium ion binding
integrin binding
ion channel binding
protein homodimerization activity
structural constituent of muscle - Gene Ontology Cellular Component:
- actin filament
cytosol
extracellular exosome
focal adhesion
intracellular
pseudopodium - Keywords:
- 3D-structure
Acetylation
Actin-binding
Calcium
Complete proteome
Metal-binding
Polymorphism
Reference proteome
Repeat