Names & Taxonomy

Uniprot ID:
Q07001
Entry Name:
ACHD_HUMAN
Status:
reviewed
Protein Names:
Acetylcholine receptor subunit delta
Gene Names:
CHRND ACHRD
Gene Names Primary:
CHRND
Organism:
Homo sapiens (Human)

Structure

Length:
517
Sequence:
MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Function

Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Cross Reference Drug Bank:
DB00674
Gene Ontology Go:
acetylcholine-gated channel complex
cell junction
plasma membrane
postsynaptic membrane
acetylcholine binding
acetylcholine-activated cation-selective channel activity
chemical synaptic transmission, postsynaptic
muscle contraction
musculoskeletal movement
neuromuscular process
neuromuscular synaptic transmission
regulation of membrane potential
response to nicotine
signal transduction
skeletal muscle contraction
skeletal muscle tissue growth
synaptic transmission
synaptic transmission, cholinergic
transport
Gene Ontology Biological Process:
chemical synaptic transmission, postsynaptic
muscle contraction
musculoskeletal movement
neuromuscular process
neuromuscular synaptic transmission
regulation of membrane potential
response to nicotine
signal transduction
skeletal muscle contraction
skeletal muscle tissue growth
synaptic transmission
synaptic transmission, cholinergic
transport
Gene Ontology Molecular Function:
acetylcholine-activated cation-selective channel activity
acetylcholine binding
Gene Ontology Cellular Component:
acetylcholine-gated channel complex
cell junction
plasma membrane
postsynaptic membrane
Keywords:
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Congenital myasthenic syndrome
Disease mutation
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Phosphoprotein
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
2564429 14702039 15815621 15489334 16916845 18398509 8872460 11782989 11435464 12499478 16959974 18252226