Names & Taxonomy

Uniprot ID:
Q05940
Entry Name:
VMAT2_HUMAN
Status:
reviewed
Protein Names:
Synaptic vesicular amine transporter (Monoamine transporter) (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2)
Gene Names:
SLC18A2 SVMT VMAT2
Gene Names Primary:
SLC18A2
Organism:
Homo sapiens (Human)

Structure

Length:
514
Sequence:
MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEIQTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSEDKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasmic vesicle membrane; Multi-pass membrane protein.

Function

Function:
Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.
Cross Reference Drug Bank:
DB00182 DB00865 DB01089 DB01576 DB01363 DB01364 DB06706 DB01577 DB00368 DB06714 DB00206 DB04844
Gene Ontology Go:
clathrin-sculpted monoamine transport vesicle membrane
dense core granule
integral component of plasma membrane
membrane
neuronal cell body
plasma membrane
synaptic vesicle
synaptic vesicle membrane
terminal bouton
amine transmembrane transporter activity
drug binding
monoamine transmembrane transporter activity
serotonin transmembrane transporter activity
aging
aminergic neurotransmitter loading into synaptic vesicle
cellular response to ammonium ion
cellular response to drug
dopamine transport
endocytic recycling
glucose homeostasis
insulin secretion
locomotory behavior
monoamine transport
negative regulation of neurotransmitter transport
negative regulation of reactive oxygen species biosynthetic process
neurotransmitter loading into synaptic vesicle
neurotransmitter secretion
post-embryonic development
response to amphetamine
response to cocaine
response to corticosterone
response to herbicide
response to starvation
response to zinc ion
sequestering of neurotransmitter
synaptic transmission
transmembrane transport
Gene Ontology Biological Process:
aging
aminergic neurotransmitter loading into synaptic vesicle
cellular response to ammonium ion
cellular response to drug
dopamine transport
endocytic recycling
glucose homeostasis
insulin secretion
locomotory behavior
monoamine transport
negative regulation of neurotransmitter transport
negative regulation of reactive oxygen species biosynthetic process
neurotransmitter loading into synaptic vesicle
neurotransmitter secretion
post-embryonic development
response to amphetamine
response to cocaine
response to corticosterone
response to herbicide
response to starvation
response to zinc ion
sequestering of neurotransmitter
synaptic transmission
transmembrane transport
Gene Ontology Molecular Function:
amine transmembrane transporter activity
drug binding
monoamine transmembrane transporter activity
serotonin transmembrane transporter activity
Gene Ontology Cellular Component:
clathrin-sculpted monoamine transport vesicle membrane
dense core granule
integral component of plasma membrane
membrane
neuronal cell body
plasma membrane
synaptic vesicle
synaptic vesicle membrane
terminal bouton
Keywords:
Alternative splicing
Complete proteome
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Membrane
Neurotransmitter transport
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
8095030 8245983 7905859 8373557 11443533 14702039 15164054 15489334 12009896 18088087