Names & Taxonomy

Uniprot ID:
Q05315
Entry Name:
LEG10_HUMAN
Status:
reviewed
Protein Names:
Galectin-10 (Gal-10) (Charcot-Leyden crystal protein) (CLC) (Eosinophil lysophospholipase) (Lysolecithin acylhydrolase)
Gene Names:
CLC LGALS10 LGALS10A
Gene Names Primary:
CLC
Organism:
Homo sapiens (Human)

Structure

Length:
142
Sequence:
MSLLPVPYTEAASLSTGSTVTIKGRPLACFLNEPYLQVDFHTEMKEESDIVFHFQVCFGRRVVMNSREYGAWKQQVESKNMPFQDGQEFELSISVLPDKYQVMVNGQSSYTFDHRIKPEAVKMVQVWRDISLTKFNVSYLKR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytosol

Function

Function:
Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).
Gene Ontology Go:
cytosol
carbohydrate binding
cysteine-type endopeptidase activity involved in apoptotic process
multicellular organism development
regulation of activated T cell proliferation
regulation of T cell anergy
regulation of T cell cytokine production
T cell apoptotic process
Gene Ontology Biological Process:
multicellular organism development
regulation of activated T cell proliferation
regulation of T cell anergy
regulation of T cell cytokine production
T cell apoptotic process
Gene Ontology Molecular Function:
carbohydrate binding
cysteine-type endopeptidase activity involved in apoptotic process
Gene Ontology Cellular Component:
cytosol
Keywords:
3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Lectin
Polymorphism
Reference proteome

Publication

PubMed ID:
8419478 1577491 9119387 19497882 15057824 15489334 16457599 17502455 19758173 22880030 24275569 8747464 10529229 11834744