Names & Taxonomy
- Uniprot ID:
- Q04844
- Entry Name:
- ACHE_HUMAN
- Status:
- reviewed
- Protein Names:
- Acetylcholine receptor subunit epsilon
- Gene Names:
- CHRNE ACHRE
- Gene Names Primary:
- CHRNE
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 493
- Sequence:
- MARAPLGVLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGAYFNRVPDLPYAPCIQP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Function
- Function:
- After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
- Cross Reference Drug Bank:
- DB00674
- Gene Ontology Go:
- acetylcholine-gated channel complex
cell junction
integral component of plasma membrane
plasma membrane
postsynaptic membrane
acetylcholine receptor activity
acetylcholine-activated cation-selective channel activity
cation transmembrane transporter activity
chemical synaptic transmission, postsynaptic
muscle contraction
neuromuscular synaptic transmission
regulation of membrane potential
response to nicotine
signal transduction
skeletal muscle contraction
synaptic transmission
synaptic transmission, cholinergic
transport - Gene Ontology Biological Process:
- chemical synaptic transmission, postsynaptic
muscle contraction
neuromuscular synaptic transmission
regulation of membrane potential
response to nicotine
signal transduction
skeletal muscle contraction
synaptic transmission
synaptic transmission, cholinergic
transport - Gene Ontology Molecular Function:
- acetylcholine-activated cation-selective channel activity
acetylcholine receptor activity
cation transmembrane transporter activity - Gene Ontology Cellular Component:
- acetylcholine-gated channel complex
cell junction
integral component of plasma membrane
plasma membrane
postsynaptic membrane - Keywords:
- 3D-structure
Cell junction
Cell membrane
Complete proteome
Congenital myasthenic syndrome
Disease mutation
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport