Names & Taxonomy
- Uniprot ID:
- Q04721
- Entry Name:
- NOTC2_HUMAN
- Status:
- reviewed
- Protein Names:
- Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
- Gene Names:
- NOTCH2
- Gene Names Primary:
- NOTCH2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 2471
- Sequence:
- MPALRPALLWALLALWLCCAAPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFECQGNSKTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQDARSFLRALGTLLHTNLRIKRDSQGELMVYPYYGEKSAAMKKQRMTRRSLPGEQEQEVAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASHAIQGTLSYPLVSVVSESLTPERTQLLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQVSEANLIGTGTSEHWVDDEGPQPKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSDLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLKHTPMGKKSRRPSAKSTMPTSLPNLAKEAKDAKGSRRKKSLSEKVQLSESSVTLSPVDSLESPHTYVSDTTSSPMITSPGILQASPNPMLATAAPPAPVHAQHALSFSNLHEMQPLAHGASTVLPSVSQLLSHHHIVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGIAPQSRPPEGKHITTPREPLPPIVTFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQQDGQVAQTILPAYHPFPASVGKYPTPPSQHSYASSNAAERTPSHSGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGAGGGQRGPGTHMSEPPHNNMQVYA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Notch 2 extracellular truncation: Cell membrane
Function
- Function:
- Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells (PubMed:25985737).
- Gene Ontology Go:
- cell surface
endoplasmic reticulum membrane
extracellular region
Golgi membrane
integral component of plasma membrane
membrane
nucleoplasm
nucleus
plasma membrane
receptor complex
calcium ion binding
receptor activity
transcription factor activity, ligand-activated RNA polymerase II transcription factor binding
apoptotic process
atrial septum morphogenesis
bone remodeling
cell cycle arrest
cell fate determination
cell growth
gene expression
hemopoiesis
intracellular receptor signaling pathway
marginal zone B cell differentiation
multicellular organism development
negative regulation of apoptotic process
negative regulation of cell proliferation
nervous system development
Notch receptor processing
Notch signaling involved in heart development
Notch signaling pathway
organ morphogenesis
positive regulation of Ras protein signal transduction
pulmonary valve morphogenesis
regulation of developmental process
regulation of transcription, DNA-templated
stem cell population maintenance
tissue regeneration
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- apoptotic process
atrial septum morphogenesis
bone remodeling
cell cycle arrest
cell fate determination
cell growth
gene expression
hemopoiesis
intracellular receptor signaling pathway
marginal zone B cell differentiation
multicellular organism development
negative regulation of apoptotic process
negative regulation of cell proliferation
nervous system development
Notch receptor processing
Notch signaling involved in heart development
Notch signaling pathway
organ morphogenesis
positive regulation of Ras protein signal transduction
pulmonary valve morphogenesis
regulation of developmental process
regulation of transcription, DNA-templated
stem cell population maintenance
tissue regeneration
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- calcium ion binding
receptor activity
transcription factor activity, ligand-activated RNA polymerase II transcription factor binding - Gene Ontology Cellular Component:
- cell surface
endoplasmic reticulum membrane
extracellular region
Golgi membrane
integral component of plasma membrane
membrane
nucleoplasm
nucleus
plasma membrane
receptor complex - Keywords:
- 3D-structure
ANK repeat
Activator
Cell membrane
Complete proteome
Cytoplasm
Developmental protein
Differentiation
Disease mutation
Disulfide bond
EGF-like domain
Glycoprotein
Membrane
Notch signaling pathway
Nucleus
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transcription
Transcription regulation
Transmembrane
Transmembrane helix