Names & Taxonomy
- Uniprot ID:
- Q04446
- Entry Name:
- GLGB_HUMAN
- Status:
- reviewed
- Protein Names:
- 1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) (Brancher enzyme) (Glycogen-branching enzyme)
- Gene Names:
- GBE1
- Gene Names Primary:
- GBE1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 702
- Sequence:
- MAAPMTPAARPEDYEAALNAALADVPELARLLEIDPYLKPYAVDFQRRYKQFSQILKNIGENEGGIDKFSRGYESFGVHRCADGGLYCKEWAPGAEGVFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSVLVPHGSKLKVVITSKSGEILYRISPWAKYVVREGDNVNYDWIHWDPEHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNMGDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRKGNNESYHYARRQFHLTDDDLLRYKFLNNFDRDMNRLEERYGWLAAPQAYVSEKHEGNKIIAFERAGLLFIFNFHPSKSYTDYRVGTALPGKFKIVLDSDAAEYGGHQRLDHSTDFFSEAFEHNGRPYSLLVYIPSRVALILQNVDLPN
- Proteomes:
- UP000005640
Function
- Function:
- Required for sufficient glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule and, consequently, in reducing the osmotic pressure within cells.
- Pathway:
- Glycan biosynthesis; glycogen biosynthesis.
- Catalytic Activity:
- Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.
- Active Site:
- ACT_SITE 357 357 Nucleophile.
- Gene Ontology Go:
- cytosol
extracellular exosome
1,4-alpha-glucan branching enzyme activity
cation binding
hydrolase activity, hydrolyzing O-glycosyl compounds
carbohydrate metabolic process
generation of precursor metabolites and energy
glucose metabolic process
glycogen biosynthetic process
glycogen metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
generation of precursor metabolites and energy
glucose metabolic process
glycogen biosynthetic process
glycogen metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- 1,4-alpha-glucan branching enzyme activity
cation binding
hydrolase activity, hydrolyzing O-glycosyl compounds - Gene Ontology Cellular Component:
- cytosol
extracellular exosome - Keywords:
- 3D-structure
Acetylation
Complete proteome
Disease mutation
Glycogen biosynthesis
Glycogen storage disease
Glycosyltransferase
Neuropathy
Phosphoprotein
Polymorphism
Reference proteome
Transferase